Extended Data Fig. 9: RyR organization in sham and failing myocytes assessed by PALM imaging.

RyR cluster density (a) and size (b), as well as overall RyR density measurements (c) were similar in sham and postinfarction heart failure (HF) myocytes, when assessed by PALM imaging. Data are presented as mean ± SEM. Differences between groups were tested with two-tailed linear mixed models with Tukey post hoc correction for multiple comparisons. n values: sham = 32 cells, 4 animals; HF = 34 cells, 3 animals.