Extended Data Fig. 2: Association of CHIP (a) and VAF (b) with incident hematologic malignancy among individuals without prevalent hematological malignancy in the UK Biobank (n = 37,657).
From: TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease
Associations are adjusted for age, age2, sex, smoking status, Townsend deprivation index, and the first ten principal components of genetic ancestry. (a) Error bars are centered at the HR and show the 95% CI for estimates. (b) Error bands reflect the standard error of a generalized binomial additive model with integrated smoothness fit to the data. CHIP = clonal hematopoiesis of indeterminate potential; VAF = variant allele fraction.
