Extended Data Fig. 1: Prox1⁺ VSs have rapid and plentiful blood flow in the mouse nasal mucosa.

a, Image showing Prox1⁺ VSs bearing blood (white arrowheads). Scale bars, 100 μm. b, Images showing Tomato-lectin binding in the Prox1⁺ VSs (white arrowheads) and capillaries at 15 min after i.v. injection. Scale bars, 100 μm. c, Images showing 2,000 kDa dextran in the Prox1⁺ VSs (white arrowheads) and capillaries (yellow arrowheads) at indicated time points after i.v. injection. Scale bars, 100 μm. Note that dextran is highly seen at 2 min, reduced at 15 min, and rarely seen at 60 min inside the Prox1⁺ VSs after the injection, while it is highly seen at 2 and 15 min in the capillaries. a–c, Similar findings were obtained from n = 4–5 mice/group from two independent experiments.