Extended Data Fig. 3: Subdivision of cardiomyocyte cluster 1 into atrial-like and pacemaker-like clusters. | Nature Cardiovascular Research

Extended Data Fig. 3: Subdivision of cardiomyocyte cluster 1 into atrial-like and pacemaker-like clusters.

From: Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Extended Data Fig. 3

(a) UMAP plot showing subdivision of cluster 1 into atrial (0, orange) and pacemaker (1, blue) subclusters, with expression of cluster specific genes, NPPA and SHOX2, inset. (b) Relative expression of SIRPA, CD200, and CD90 in cluster 1, indicating the presence of SIRPA + /CD200 + /CD90− arrhythmogenic PSC-CMs predominantly in the atrial sub-cluster. (c) List of GO terms for differentially expressed genes between atrial and pacemaker subclusters. The Fisher’s exact test was used to determine statistical significance.

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