Extended Data Fig. 7
Network plots depicting significantly enriched gene sets in cardiac fibroblasts from (a) T cellLow and (b) T cellHigh groups according to GO enrichment analysis based on differentially expressed genes in snRNA-seq analysis of cardiac EMBs. (c) Correlation analysis BMP4 mRNA expression and T cell infiltration in EMBs. Colors indicate the proportion of infiltrating T cells. High, red dots (>6%, T cellHigh); intermediate, green dots (3–6%, T cellInt) and low, blue dots (<3%, T cellLow) proportions of heart-infiltrating T cells. (d, e) Multiparametric correlation analysis between proportions of infiltrating cardiac cells and genes of the BMP family. (d) Pearson’s correlation comparisons of indicated cell type abundances and expression of indicated genes. (e) P values from the Pearson’s correlation comparisons in (d). Statistical analysis was performed using simple linear regression test (c).
