Extended Data Fig. 3: Activation of cardiac fibroblasts. | Nature Cardiovascular Research

Extended Data Fig. 3: Activation of cardiac fibroblasts.

From: Bone morphogenic protein-4 availability in the cardiac microenvironment controls inflammation and fibrosis in autoimmune myocarditis

Extended Data Fig. 3

(a) Computationally predicted murine BMP4-BMPR1a/BMPR2 interactions by cells in the homeostatic and inflamed cardiac microenvironment based on sc/snRNA-seq data using the CellChat tool. (b) Representative confocal images of Bmp4-deficient (EYFP+) and Bmp4-proficient (EYFP−) fibroblasts after 10 days of culture. (c, d) Production of BMP4 (c) and IL-6 (d) measured by ELISA from Bmp4-proficient (EYFP−) fibroblasts cardiac fibroblasts exposed IL-1β (1 ng/ml) or left untreated (medium) for 24 h. Box and whiskers show min to max, mean ± interquartile range. (N = 6; pooled data from two independent experiments). Statistical analysis was performed using Student’s t test (c-d) with ***, p < 0.001.

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