Extended Data Fig. 6: Mlkl knockdown potentiates the expansion of splenic stem and progenitor cells.
From: Hyperlipidemia-induced hematopoiesis is repressed by MLKL in endothelial cells of the splenic niche
a,b, Flow cytometry quantification of splenic hematopoietic stem, progenitor (a) and mature (b) populations in Apoe-/- mice after 16 weeks of treatment. n = 10 mice per group. c,d, Total number of splenocytes per spleen (c; control n = 7 mice, Mlkl KD n = 8 mice) and bone marrow cells per leg (d; control n = 18 mice, Mlkl KD n = 11 mice). e, Flow cytometry quantification of hematopoietic stem and progenitors in the livers of Apoe-/- mice after 8 weeks of treatment. n = 5 mice per group. Data are shown as mean ± s.e.m. Statistical significance was determined by two-tailed unpaired t-test (a, c & e) or two-tailed Mann-Whitney test (b & d).
