Extended Data Fig. 3: Detail of the Electrostatic Bond Involving the Carboxyl Group of a Conserved Leucine. | Nature Cardiovascular Research

Extended Data Fig. 3: Detail of the Electrostatic Bond Involving the Carboxyl Group of a Conserved Leucine.

From: Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy

Extended Data Fig. 3

(A) L267 from β-cardiac myosin interacts with the N-H from aficamten. (B) L262 from D. discoidum Myosin II interacts with the hydroxyl group of blebbistatin (PDB code 1YV3, ref. 37). (C) The same kind of interaction occurs between L270 from skeletal myosin II and the hydroxyl of MPH-220 (PDB code 6YSY, ref. 38).

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