Table 2 Effect of aficamten on the single nucleotide turnover rate of cardiac myosin S1

From: Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy

Treatment

N

% Slow turnover

kfast (s−1)

kslow (s−1)

Vehicle

15

6.4 ± 4.5

0.030 ± 0.004

0.0014 ± 0.0008

25 μM aficamten

25

100a*

N/A

0.00043 ± 0.0002*

  1. Data are presented as mean ± s.d. aTraces for reactions containing aficamten were equally well fit by single equation (2) and double exponential equation (3). *P < 0.0001 versus vehicle calculated using a two-tailed unpaired t-test. N/A, not available; kfast, fast rate constant; kslow, slow rate constant.
Back to article page