Extended Data Fig. 9: Overview of VEC scRNA-seq from Pulmonary Valves with Pulmonary Stenosis.
From: APOE–NOTCH axis governs elastogenesis during human cardiac valve remodeling
a. Feature plots of markers genes for each VEC subtype combining valves from one control and one patient with PS; b. Violin plots comparing JAG1 expression between three VEC subtypes; c. Immunofluorescence staining and percentage of NOTCH1+ & NOTCH3+ VICs in Elastin layer VICs in pulmonary valve tissues from control vs. PS. n = 3 different samples in each group. Data shown as ± SEM. **p < 0.01, ***p < 0.001, control vs. PS. Statistics in c: Unpaired 2-tailed t-test (two groups). P value in c: NOTCH1: p = 0.0493, NOTCH3: p = 0.0002.
