Extended Data Fig. 1: scRNA-seq of Normal Human Fetal Heart Valves.
From: APOE–NOTCH axis governs elastogenesis during human cardiac valve remodeling
a. Violin plot of doublet score, mitochondria percentage, number of counts, and number of features across all valves after quality control: nCount RNA < 1e5, nFeature RNA > = 1000, pMT < 10, Doublet score <0.3. A/P/M/T represent Aortic, Pulmonary, Mitral, Tricuspid valves respectively; b. UMAP visualization of cells from four different human fetal valves from two week-15 healthy hearts after integration by Canonical Correlation Analysis (CCA); c. Left: Cell number and proportion of each valve in each cell type. Right: Dot plot of representative marker genes within each valve cell type; d. Feature plot of representative marker genes in each valve cell type; e. UMAP visualization of four different human fetal valves within VICs; f. Left: Bar graph showing proportions of each valve within each VIC subtype. Right: Bar graph showing proportions of each VIC subtype within each valve; g. Feature plots for marker genes for each VIC subtype in VICs.
