Extended Data Fig. 2: Re-analysis of Public Human Fetal and Mouse Postnatal Heart Valve scRNA-seq Datasets.
From: APOE–NOTCH axis governs elastogenesis during human cardiac valve remodeling
a. UMAP visualization of postnatal mouse valve cell types (Hulin et al., 2019); b. Feature plot of representative marker genes within each cell type within mouse valves; c. Development stage visualization (P7 and P30) and feature plots of representative marker genes for each VIC subtype; d. UMAP visualization showing mouse VIC subtypes similar to human GAG-VICs (Left) and Collagen-VICs (Right) through reverse projection; e. UMAP presentation of newly discovered Elastin-VICs, CLDN11-VICs, and Proliferative-VICs; f. UMAP visualization of human fetal valve in W22, W23, and W25 (Cui et al., 2019) integrated by CCA; g. Feature plot of representative marker genes of each cell type in Cui et al, 2019. h. UMAP visualization of VICs in W22, W23, and W25 (Cui et al., 2019).
