Extended Data Fig. 1: Distribution of comorbidities in the Johns Hopkins HFpEF cohort.
From: Myocardial ultrastructure of human heart failure with preserved ejection fraction
The figures show distributions for systolic blood pressure (SBP), left ventricular mass index (LV Mass I), and body mass index (BMI) from a myocardial biopsy cohort of 111 HFpEF patients. For each, low-to-high quartiles were assigned a rank of 0 to 3, and a hemodynamic versus metabolic score was determined for each patient. The ratio of one to the other (corrected for the theoretical maximal sum) was determined, and the upper and lower quintile of this ratio was used as the source of patients in the H/H versus Obese groups. The mixed group had the elevated rank scores for both sets of variables. Blue lines show 25th and 75th percentiles, red bar shows median. For BMI data, patients with a history of diabetes (all Type 2) are shown by the dark color, those without by the light color. They were distributed throughout each quartile of BMI.
