Extended Data Fig. 7: Dual contribution of trabeculae during neonatal cardiac regeneration.

Trabeculae participate in the regeneration of the contractile myocardium, and are thus found in increased proportions in regenerated myocardium. However, this contribution to the myocardium involves a perdurance of an immature phenotype in the trabeculae during regeneration which prolongs the plasticity between the contractile and conductive fates and results in ectopic conductive commitment. Excessive production of conductive cells is accompanied by incomplete conductive maturation producing a hyperplastic and immature PF network and resulting in altered ventricular conduction.