Extended Data Fig. 1: Ventricular trabeculae during development and repartition of their derivatives in the mature heart. | Nature Cardiovascular Research

Extended Data Fig. 1: Ventricular trabeculae during development and repartition of their derivatives in the mature heart.

From: Participation of ventricular trabeculae in neonatal cardiac regeneration leads to ectopic recruitment of Purkinje-like cells

Extended Data Fig. 1

(a) Longitudinal sections of hearts from Cx40-Cre-RFP mice. Cx40 is expressed in the trabeculae, as seen by RFP expression, thus, genetic labeling in Cx40-CreERT2 mice labels CM from the trabeculae. (b) Cartoons summarizing the geometry of the trabeculae and the repartition of their derivatives at fetal, perinatal and mature stages. At E14.5, the trabeculae (cyan) reach their higher density. Thereafter, they progressively coalesce and give rise to subendocardial CMs (light green). Around birth, the innermost part of the embryonic trabeculae is not yet compacted, we call this area ‘perinatal trabeculae’. The perinatal trabeculae give rise to the most subendocardial CMs (dark green) and to the PF network. The compact myocardium and its derivatives are shown in dark gray and gray, respectively. Concomitant with trabeculae compaction, bipotent progenitor from the trabeculae progressively segregate between conductive (purple) and contractile (green) fate. Final maturation extends until the third week of mice life.

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