Extended Data Fig. 6: Organized clots in Ccm3-iECKO mice reduce vessel perfusion. | Nature Cardiovascular Research

Extended Data Fig. 6: Organized clots in Ccm3-iECKO mice reduce vessel perfusion.

From: Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation

Extended Data Fig. 6

(a): Representative scanning electron microscopy image of a perfused Ccm3-iECKO mice showing acute (I) and organized clot (II-III) areas. Insets at the bottom are close-up views of the dashed areas marked I-III. Inset figure (a) represents the red dashed area in figure II. Figure (b) from orange dashed area and figure (c) from green dashed area, both in figure III. Asterisks highlight collateral vessels. Arrow heads highlight erythrocytes. The stains were repeated independently in all the samples (n = 10) with similar results (b): Representative image of the cerebellum of Ccm3-iECKO vehicle mice stained via RNAscope with DAPI (blue), Ubc (white) Polr2a (green), Ppib (red) and Cldn5 (magenta; consecutive section). Showing intense reduction of housekeeping genes around organized clots. The stains were repeated independently in all the samples (n = 10) with similar results.

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