Extended Data Fig. 8: Organized clots in human CCMs. | Nature Cardiovascular Research

Extended Data Fig. 8: Organized clots in human CCMs.

From: Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation

Extended Data Fig. 8

(a–d) Representative images of familial CCM (fCCM) patients showing acute or organized clots. Samples were stained for CD34 (top panel), and Fraser-Lendrum stain (normal red blood cells (yellow), fibrin coated red blood cells (purple), collagen (turquoise). Using Fraser-Lendrum stain, organized clots having increased collagen deposition are shown and contrasted with acute clots without collagen deposition. Insets with dashed, black line are shown in the magnifications below. Black arrows highlight the organized clots. (e-j) Representative images of sporadic CCM (sCCM) patients showing acute or organized clots in stained with DAPI (blue), vWF (green), α-SMA (red). Insets with dashed, white line are shown in the magnifications to the right. White arrows highlight the organized clots. For all images the stains were repeated independently in all the samples with similar results.

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