Extended Data Fig. 9: Effect of NET inhibition on mouse weight, and cytokines. | Nature Cardiovascular Research

Extended Data Fig. 9: Effect of NET inhibition on mouse weight, and cytokines.

From: Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation

Extended Data Fig. 9

(a) Macroscopic images of mouse brains used in study. Brains within the box with dashed lines are wild type mice. (b) Quantification of mouse weight and sex distribution across Cl-amidine treated vs vehicle groups. Open and filled circles represent females and open and filled triangles represent males. (c) Quantification of adverse effects (death or balance issues) in Ccm3-iECKO mice used in the study. (d–k) Quantification of IL-1β (d), IL-6 (e), IP-10 (f), TNF (g), KC/GRO (h), MCP-1 (i), MIP-1α (j), MIP-2 (k) levels in the plasma of Ccm3-WT vehicle and Cl-amidine (10 mg/kg/day) treated mice.

Back to article page