Fig. 8: Graphical summary of findings. | Nature Cardiovascular Research

Fig. 8: Graphical summary of findings.

From: Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation

Fig. 8

Representative summary of the findings of this study. In CCM, neutrophils become activated, leading to the release of NETs (1). These NETs trigger or exacerbate processes dysregulated in CCM: endothelial activation and EndMT (2a), neuroinflammation (2b), coagulation and clot organization (2c), fibroblast activation (2d) and increased collagen deposition (2e). The graphical abstract was created with BioRender.

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