Extended Data Fig. 6: Macroscopic images of aortas of mice infused with Ang II, and the effect of ablation of Nampt, Nmnat1, or Slc25a51 in smooth muscle cells on aortic NAD+ level and blood pressure. | Nature Cardiovascular Research

Extended Data Fig. 6: Macroscopic images of aortas of mice infused with Ang II, and the effect of ablation of Nampt, Nmnat1, or Slc25a51 in smooth muscle cells on aortic NAD+ level and blood pressure.

From: Mitochondrial NAD+ deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm

Extended Data Fig. 6

a, Photographic images show whole aortas of mice that died from aortic rupture (right) and surviving mice euthanized at the end of 6-week experiment (left). Representative macroscopic images were shown in Fig. 5. Scale bar: 1 cm. b, Ablation of Nampt (n = 5), Nmnat1 (n = 5), or Slc25a51 (n = 5) in smooth muscle cells reduced aortic NAD+ level. c, Comparison of NAD+ levels in the skeletal muscle (n = 4), liver (n = 4) and heart (n = 4) tissues between 3-month-old and 12-month-old mice. d, Ablation of Nampt (n = 5), Nmnat1 (n = 5), or Slc25a51 (n = 5) in 40-week-old smooth muscle cell-specific knockout male mice did not alter diastolic or systolic blood pressure. Data are represented as mean ± standard deviation, p-values were determined by two-tailed Studentʼs t-tests. BP, blood pressure.

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