Extended Data Fig. 7: The effect of Nadk2 ablation on vascular pathology.
a, The experimental outline of spontaneous aortic dilation in mice. Ultrasonography was performed at 50 weeks of age. b, Representative aortic ultrasound images of 50 weeks old Myh11-CreERT2 (n = 6) and SMC-Nadk2−/− (n = 7) male mice. c, Representative aortic ultrasound images of 50 weeks old male mice. Scale bar: 1 mm. d, Representative histologic images showing HE and EVG section staining of ascending thoracic aorta. Scale bar: 100 μm and 50 μm. Data are represented as mean ± standard deviation, p-values were determined by two-tailed Studentʼs t-tests. The ultrasound data of Myh11-CreERT2 mice in Extended Data Fig. 5f, g, Extended Data Fig. 7b and main text Fig. 4d, e are identical (that is, representing the same data) to minimize the necessity for additional mice sacrifices.
