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Gut microbiota

A perspective on thrombogenesis through gut microbiota-derived bile acids and platelet activation

Nature Cardiovascular Research volume 4, pages 505–507 (2025)Cite this article

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Cardiovascular arterial thrombosis poses a major health burden, despite intensive antiplatelet therapy, and platelet hyper-reactivity drives thrombus formation, yet its molecular mechanisms remain unknown. A study now shows that gut microbiota–derived deoxycholic acid modulates platelet activity and thrombosis risk in coronary artery disease.

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Fig. 1: Role of bile acids in atherothrombosis.

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Acknowledgements

C.M. is funded by the Chronic Disease Research Foundation (CDRF) and by the Italian Ministry of Education and Research (MUR): Dipartimenti di Eccellenza Program 2023–2027. A.M.V. is supported by the National Institute for Health and Care Research Nottingham Biomedical Research Centre. Support for this work was also provided by UKRI/MRC grants (MR/W026813/1 and MR/Y010175/1) awarded to A.M.V. and C.M.

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Authors and Affiliations

  1. Department of Twin Research & Genetic Epidemiology, King’s College London, London, UK

    Cristina Menni

  2. Department of Pathophysiology and Transplantation, Università Degli Studi di Milano, Via Francesco Sforza, Milan, Italy

    Cristina Menni

  3. Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy

    Cristina Menni

  4. Academic Rheumatology Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, Nottingham, UK

    Ana M. Valdes

  5. NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK

    Ana M. Valdes

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  1. Cristina Menni
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  2. Ana M. Valdes
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Correspondence to Cristina Menni or Ana M. Valdes.

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Menni, C., Valdes, A.M. A perspective on thrombogenesis through gut microbiota-derived bile acids and platelet activation. Nat Cardiovasc Res 4, 505–507 (2025). https://doi.org/10.1038/s44161-025-00634-0

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