Extended Data Fig. 4: Genome-wide association analysis of metabolite 3BH5C GWAS in the HELIOS cohort (N = 1,876).

(a) Manhattan plot of 3BH5C GWAS where x-axis is displaying position of genetic variants on chromosome (hg38), and y-axis is displaying the strength of association of genetic variants with mean-cIMT. Horizontal red line indicates a GWAS threshold of P = 5×10^-8. The top variant is rs2051466 (P = 7.9x10^-43). (b) Quantile-Quantile plot of 3BH5C GWAS (λ_GC = 1.002) where x- and y-axes indicate the expected P-values under a null distribution and the observed P-values, respectively.