Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Lymphatic vessels

Collecting lymphatics unzip to drain injured lungs

Nature Cardiovascular Research volume 4, pages 959–961 (2025)Cite this article

Subjects

Protease-activated receptor 1 (PAR1) allows platelets and blood endothelial cells to respond to coagulation. Research in mouse models has uncovered a new role for PAR1 — enabling pulmonary collecting lymphatics to transform their intercellular junctions from ‘zippers’ into ‘buttons’ for additional interstitial fluid drainage during acute lung injury.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: PAR1-dependent changes in pulmonary collecting lymphatic junctions and lung lymph flow during acute lung injury.

References

  1. Baluk, P. & McDonald, D. M. Cold Spring Harb. Perspect. Med. 12, a041178 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Churchill, M. J. et al. J. Exp. Med. 219, e20211830 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Suh, S. H. et al. EMBO Rep. 20, e46927 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Chou, C. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-025-00681-7 (2025).

    Article  PubMed  Google Scholar 

  5. Lei, D. et al. iScience 24, 103386 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Cleary, S. J. et al. J. Exp. Med. 222, e20241359 (2025).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Schoofs, H. et al. Nature 641, 465–475 (2025).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. MacDonald, M. E. et al. Blood Adv. 6, 6249–6262 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Zhang, P. et al. JCI Insight 9, e173440 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Künze, G. & Isermann, B. Blood 141, 2675–2684 (2023).

    PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pharmaceutical Science, King’s College London, London, UK

    Simon J. Cleary

Authors
  1. Simon J. Cleary
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Simon J. Cleary.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cleary, S.J. Collecting lymphatics unzip to drain injured lungs. Nat Cardiovasc Res 4, 959–961 (2025). https://doi.org/10.1038/s44161-025-00682-6

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s44161-025-00682-6

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing