Extended Data Fig. 9: Additional functional MRI parameters of Lyve1 KO hearts 28-days after MI at P1 and P7.
From: Cardiac lymphatics retain LYVE-1-dependent macrophages during neonatal mouse heart regeneration
Plots from longitudinal cine MRI performed on Lyve1+/− and Lyve1−/− mice 28 days after MI at P1 and P7, as well as in intact control littermates at comparable P29 and P35 stages (A,B). MRI revealed significantly reduced end diastolic mass (EDM), end systolic mass (ESM), and heart weight (hwt) in P1 Lyve1−/− mice at 28 days post-MI compared to Lyve+/− MI controls at the equivalent timepoint (A). Conversely, EDM, ESM, and hwt were all significantly increased in Lyve1−/− mice injured at P7 at 28-days post-MI compared to Lyve1+/− 28dpi controls (B). Data are presented as mean ± SD; n = 6 for P29 control, n = 7 for P1MI28dpi control, n = 8 for P29 Lyve1−/− n = 7 for P1MI28dpi Lyve1−/−. n = 8 for P35 control, n = 7 for P7MI28dpi control, n = 8 for P35 Lyve1−/− n = 10 for P7MI28dpi Lyve1−/−. Significant differences were calculated using 2-way ANOVA.
