Extended Data Fig. 4: ANTXR1 promotes collagen remodeling following myocardial infarction.
From: ANTXR1 blockade enhances cardiac function in preclinical models of heart failure
a) Immunofluorescence staining with a collagen hybridizing peptide (CHP, red) was used to evaluate the levels of denatured collagen in the left ventricular wall of ANTXR1 wildtype (WT) and knockout (KO) at day 7 or 14 post-myocardial infarction (MI). All cardiac fibroblasts were labeled with wheat germ agglutinin (WGA, magenta). Bar = 20 µm. b) Quantification of staining shown in A. Data represent the mean ± SEM from independent hearts samples indicated by the use of different colors/shapes. For each sample, multiple fields were imaged (small symbols), and the larger symbol corresponds to the average of that sample. P values were assessed using a one-way ANOVA with Tukey’s multiple-comparisons test. *P < 0.05, **P < 0.01, ****P < 0.0001.
