Fig. 6: Ketamine blocked neuronal responses to ultrasound, not to sound in the auditory cortex.
From: Low frequency ultrasound elicits broad cortical responses inhibited by ketamine in mice
a Heatmaps showing Ca2+ responses to 50% duty cycle 40 kHz ultrasound and 12 kHz sound under isoflurane and ketamine anesthesia. b Average Ca2+ traces in response to 50% ultrasound and sound under isoflurane and ketamine. Note that no apparent increase in Ca2+ signals during ultrasound exposure under ketamine, while sound responses remained (n trial number, N animal number). c Comparison of AUC during 20-s ultrasound and sound exposures between isoflurane and ketamine. Significantly lower AUCs for ultrasound in ketamine were observed, whereas no significant difference in AUCs during sound exposure between isoflurane and ketamine (data expressed as mean ± SEM, Statistics: Mann–Whitney test in (c). ****P < 0.0001).
