Table 1 Comparison of treatment variables across classes of the five-class model

From: Trajectories of improvement with repetitive transcranial magnetic stimulation for treatment-resistant major depression in the BRIGhTMIND trial

Ā 

Class 1 Strong (n = 27)

Class 2 Delayed-Mod (n = 54)

Class 3 Plateau-Mod (n = 47)

Class 4 Non-impr. (n = 88)

Class 5 Worse (n = 12)

Tests of differences

Medication change

No 81.5% Yes 18.5%

75.9% 24.1%

78.7% 21.3%

76.1% 23.9%

83.3% 16.7%

χ2(4) = 0.691, p = 0.952

Treatment adjusted

No 70.4% Yes 29.6%

85.2% 14.8%

66.0% 34.0%

67.0% 33.0%

83.3% 16.7%

χ2(4) = 7.424, p = 0.115

Intensity (percent)

55.5 (50.6–60.4)

55.5 (52.0–59.0)

50.7 (46.9–54.5)

51.6 (48.9–54.4)

53.5 (46.2–60.8)

F(4,215) = 1.374, p = 0.244

(cgiTBS group) Mean target co-ordinate (MNI)

āˆ’42/25/33

āˆ’40/22/36

āˆ’41/23/34

āˆ’41/21/37

āˆ’43/22/38

V(Pillai’s Trace) = 0.052, F(12,312) = 0.455, p = 0.939

Mean dist. from targeta (mm)

7.0 (4.8–9.7)

5.8 (4.4–7.5)

5.7 (4.2–7.6)

5.1 (4.1–6.3)

3.9 (1.9–6.9)

F(4,215) = 0.946, p = 0.438

Mean dist. from sess. 1a (mm)

7.6 (5.7–9.9)

6.4 (5.2–7.9)

6.8 (5.4–8.5)

5.6 (4.7–6.6)

4.8 (2.9–7.5)

F(4,213) = 1.325, p = 0.262

SD of dist. from sess. 1a (mm)

4.9 (3.7–6.4)3–5

3.3 (2.6–4.1)

2.9 (2.2–3.8)1

2.8 (2.3–3.3)1

2.1 (1.2–3.6)1

F(4,213) = 3.215, p = 0.014*, Ī·p2 = 0.057

Networks stimulated

3.0 (2.3–3.6)3–5

2.3 (1.8–2.7)5

1.7 (1.2–2.2)1

1.6 (1.3–2.0)1

1.1 (0.1–2.0)1,2

F(4,205) = 4.716, p = 0.001**, Ī·p2 = 0.084

Within-session SD of dist. (mm)a

2.3 (1.7–3.1)

1.8 (1.4–2.2)

1.9 (1.5–2.4)

1.6 (1.3–1.9)

1.1 (0.6–1.9)

F(4,213) = 2.080, p = 0.084^, Ī·p2 = 0.038

(cgiTBS group) Target distance from āˆ’44/40/29a

19.1 (14.4–24.8)

22.4 (18.5–26.7)

19.6 (16.3–23.4)

23.4 (20.3–26.8)

21.1 (14.2–29.9)

F(4,105) = 0.863, p = 0.489

  1. For binary variables, values are percentage of patients. For continuous variables, values are means with 95% confidence intervals. Tests of significance of differences across classes are given in the final column (^p < 0.1, *p < 0.05, **p < 0.01). For significant variables, superscript numbers denote pairs of classes with significant pairwise differences at the p < 0.05 level (superscripts correspond to class numbers, such that a superscript of 4 indicates a significant difference from class 4).
  2. aStatistical analyses performed on the cube root of values due to right skew of values across patients (presented values are back transformed).