Fig. 4: Between-group differences in network strength of the FC (n = 91 biologically independent samples) and SC (n = 90 biologically independent samples) profiles.
From: Multimodal brain connectome-based prediction of suicide risk in people with late-life depression
One-way ANOVA and non-parametric Kruskal–Wallis tests based on normality testing using the Kolmogorov–Smirnov test (two tailed) were used. False-discovery rate correction was conducted to correct for multiple comparisons. Post hoc analyzes were Bonferroni corrected. Regarding FC, the negative network profiles of BSS and SPS showed significant group differences (BSS, H(2) = 9.94, Pcorr = 0.016; SPS, H(2) = 31.38, Pcorr = 9.2 × 10−7), while that of TSII did not (all P > 0.65, false-discovery rate corrected). Follow-up Dunn–Bonferroni tests revealed that the SA group showed significantly lower network strength compared with the NS (BSS, H = 19.24, Pcorr = 0.009; SPS, H = 36.25, Pcorr = 7.0 × 10−8) and IP groups (BSS, H = 17.36, Pcorr = 0.049; SPS, H = 17.42, Pcorr = 0.048), and the IP group showed lower network strength compared with the NS group (SPS, H = 18.84, Pcorr = 0.020). Regarding SC, only the positive network profiles of SPS demonstrated significant group differences (SPS, H(2) = 9.65, Pcorr = 0.016). Follow-up analyzes revealed that the NS group had significantly lower network strength than the SA group (SPS, H = −19.07, Pcorr = 0.009). These results remained unchanged after controlling for sex, age, education, MMSE, HAMD/A, onset time of LLD, number of episodes of LLD, duration of LLD, the five types of medication, number of medication types, medication load or mean frame-wise displacement (FD). Moreover, these connectivity profiles were not significantly correlated with age or medication load (Supplementary Table 5). The network strength values were standardized for visualization. The lower and upper bounds of the box inside the violin represent the first and third quartiles. The length of the whiskers represents no more than 1.5 times the interquartile range from the bound to the maxima (upper whisker) or to the minima (lower whisker). Data beyond the end point of the whiskers are shown as individual dots. ‘n.s.’ indicates no significant difference between the two groups. ***P < 0.001, **P < 0.01, *P < 0.05.
