Table 4 Regression analyses, stratified by early-onset versus late-onset depression

	Standardized β	T	P	Collinearity statistics: variance inflation factor^a
Early-onset depression (age of onset before 65 years)
F(6, 349) = 19.02, P < 0.001, adjusted R² = 0.23 and power >0.99
Age	0.13	2.65	0.008	1.06
Sex	−0.20	−4.24	<0.001	1.02
Depression and anxiety severity	−0.030	−0.65	0.52	1.03
Cognitive functioning	−0.082	−1.73	0.084	1.05
Cardiovascular and cardiometabolic health	0.40	8.55	<0.001	1.02
Blood pressure	0.030	0.64	0.52	1.02
Late-onset depression (age of onset at or after 65 years)
F(6, 62) = 3.53, P = 0.005, adjusted R² = 0.18 and power 0.82
Age	0.25	2.11	0.039	1.14
Sex	−0.14	−1.15	0.25	1.20
Depression and anxiety severity	−0.089	−0.77	0.45	1.11
Cognitive functioning	−0.095	−0.82	0.41	1.11
Cardiovascular and cardiometabolic health	0.39	3.40	<0.001	1.10
Blood pressure	−0.012	−0.10	0.92	1.11

We conducted additional exploratory two-tailed regression analyses to assess whether the age of onset influences the relationships above. P values less than 0.0083 (Bonferroni correction for six covariates) are considered significant and bolded.
^aThe variance inflation factor is used to detect multicollinearity. The value starts at 1 and has no upper limit. A general rule of thumb is that values between 1 and 5 indicate some correlations that are not problematic enough to require attention.

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