Fig. 5: Statistical comparisons between subject-level ICN estimates from healthy controls and individuals with schizophrenia.

a–d, Comparisons between subject-level temporal (TEMP) (a), secondary sensorimotor (MTR2) (b), posterior default mode (pDM) (c) and unique explicitly nonlinear (ENL) (d) ICN estimates derived from healthy controls (HC) and individuals with schizophrenia (SZ). Results are plotted according to a dual-coded colormap86, with transparency reflecting two-sided independent-samples t-statistic magnitudes and contours indicating FDR-corrected statistical significance (q < 0.05). In a–c, results from LIN comparisons are located on the left, and results from ENL comparisons are located on the right. Warmer hues indicate HC > SZ, and cooler hues indicate SZ > HC. Results are overlaid on the ch2bet template with x, y and x coordinates listed relative to the origin in Montreal Neurological Institute 152 space.