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Effects of pandemic-related stressors on anxiety and mood difficulty during versus before the COVID-19 pandemic in US Army soldiers and veterans

Abstract

Military personnel are routinely involved in pandemic relief efforts, placing them at risk of increased exposure to pandemic-related stressors. Although ample research suggests that exposure to pandemic-related stressors contributed to decrements in mental health among civilians during the COVID-19 pandemic, limited work has examined whether these patterns were also salient in military populations. Here we report data on The Army Study to Assess Risk and Resilience in Servicemembers (STARRS) Longitudinal Study, which screened for 30-day prevalence of major depressive episode, generalized anxiety disorder, post-traumatic stress disorder and panic attack among 10,206 US Army soldiers and veterans before (2018–2019) and then again during (2020–2022) the COVID-19 pandemic. Statistically significant increases were found in prevalence, with relative risk (RR) comparable to that observed in civilian samples (RR 1.28–1.40). The greatest increases were observed among women, Black and Hispanic individuals, those of lower socioeconomic status and Regular Army soldiers compared with reservists and those separated from service. Exposures to pandemic-related stressors, although associated with significantly increased mental health difficulty (RR 1.06–1.17), did not explain associations of sociodemographics and Army career characteristics with difficulty RR. No significant interactions were found between pandemic-related stressors and either baseline difficulty prevalence, sociodemographics or Army career characteristics predicting difficulty RR. Results suggest that military personnel may experience pandemic-related declines in mental health similar to those observed in civilian populations, with the largest changes occurring among individuals with greater socioeconomic vulnerability and/or higher exposure to pandemic-related stress. Findings emphasize the importance of ensuring accessibility to appropriate support for military personnel during pandemic conditions.

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Data availability

STARRS-LS Wave 1, Wave 2 and Wave 3 data, as well as data from the earlier Army STARRS New Soldier Study, All Army Study and Pre and Post Deployment studies, are available through the Inter-university Consortium for Political and Social Research (ICPSR) at the University of Michigan (https://www.icpsr.umich.edu/web/ICPSR/studies/35197). STARRS-LS and Army STARRS data are restricted from general dissemination, meaning that a confidential data use agreement must be established before access. Researchers interested in gaining access to the data can submit their applications via ICPSR’s online Restricted Contracting System. Guidelines for applying for access to this data can be found under the data and documentation tab at the above URL. The STARRS Historical Administrative Data Study data are not available for public release.

Code availability

Code used to produce the statistical output is available via GitHub at https://github.com/kingme5005/COVID_ls2_ls3. Because the data used in this study are not publicly available and require DoD clearance to access, we cannot post the source code used to read in the Army administrative data (which requires DoD clearance) and create the 2,000+ variables used in this analysis.

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Acknowledgements

The Army STARRS Team consists of Co-Principal Investigators: R.J.U. (Uniformed Services University) and M.B.S. (University of California San Diego and VA San Diego Healthcare System). Site Principal Investigators: J.R.W. (University of Michigan) and R.C.K. (Harvard Medical School). Army scientific consultant/liaison: K. Cox (Office of the Assistant Secretary of the Army (Manpower and Reserve Affairs). Other team members: P. A. Aliaga (Uniformed Services University); D. M. Benedek (Uniformed Services University); L. Campbell-Sills (University of California San Diego); C. S. Fullerton (Uniformed Services University); N. Gebler (University of Michigan); M. House (University of Michigan); P. E. Hurwitz (Uniformed Services University); S. Jain (University of California San Diego); T.-C. Kao (Uniformed Services University); L. Lewandowski-Romps (University of Michigan); A. Luedtke (University of Washington and Fred Hutchinson Cancer Research Center); H. Herberman Mash (Uniformed Services University); J. A. Naifeh (Uniformed Services University); M. K. Nock (Harvard University); N. Hani Zainal (Harvard Medical School); N.A.S. (Harvard Medical School); and A. M. Zaslavsky (Harvard Medical School). Army STARRS was sponsored by the Department of the Army and funded under cooperative agreement number U01MH087981 (2009–2015) with the National Institute of Mental Health (NIMH). Subsequently, STARRS-LS was sponsored and funded by the Department of Defense (USUHS grant number HU0001-15-2-0004). E.R.E. was supported in part by the US Department of Veterans Affairs, Clinical Sciences Research and Development Service (CSR&D) VA-STARRS Researcher-in-Residence Program (Project SPR-002-24F). The contents are solely the responsibility of the authors and do not necessarily represent the views of the NIMH, the Department of the Army, the Department of Defense or the Department of Veteran Affairs.

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R.C.K. and A.M.M.-B.: concept and design. R.C.K., A.M.M.-B., E.R.E., A.J.K., H.L., M.V.P., N.A.S., H.N.Z., J.R.W., M.B.S. and R.J.U.: acquisition, analysis or interpretation of data. R.C.K., A.M.M.-B. and E.R.E.: drafting of the manuscript. A.J.K., H.L. and M.V.P.: statistical analysis. R.C.K., M.B.S. and R.J.U.: obtained funding. R.C.K., A.M.M.-B., S.M.G., N.A.S., J.R.W., M.B.S. and R.J.U.: technical, administrative or material support. R.C.K., A.M.M.-B. and N.A.S.: supervision. All authors: critical revision of the manuscript for important intellectual content and approved final version for submission.

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Correspondence to Ronald C. Kessler.

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Competing interests

In the past 3 years, R.C.K. was a consultant for Cambridge Health Alliance, Canandaigua VA Medical Center, Child Mind Institute, Holmusk, Massachusetts General Hospital, Partners Healthcare, Inc., RallyPoint Networks, Inc., Sage Therapeutics and University of North Carolina. He has stock options in Cerebral Inc., Mirah, PYM (Prepare Your Mind), Roga Sciences and Verisense Health. In the past 3 years, M.B.S. received consulting income from Actelion, Acadia Pharmaceuticals, Aptinyx, atai Life Sciences, Boehringer Ingelheim, Bionomics, BioXcel Therapeutics, Clexio, EmpowerPharm, Engrail Therapeutics, GW Pharmaceuticals, Janssen, Jazz Pharmaceuticals and Roche/Genentech. He has stock options in Oxeia Biopharmaceuticals and EpiVario. He is paid for his editorial work on Biological Psychiatry (Deputy Editor) and UpToDate (Co-Editor-in-Chief for Psychiatry). The other authors declare no competing interests.

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Kessler, R.C., Millikan-Bell, A.M., Edwards, E.R. et al. Effects of pandemic-related stressors on anxiety and mood difficulty during versus before the COVID-19 pandemic in US Army soldiers and veterans. Nat. Mental Health 3, 1191–1201 (2025). https://doi.org/10.1038/s44220-025-00505-4

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