Table 1 Baseline characteristics of participants by disease status

From: Blood cell biomarker trajectories and depression risk in a sex-stratified 10-year longitudinal cohort analysis

Characteristics

Disease status

P value

Overall (n = 87,493)

Depression (n = 650)

Non-depression (n = 86,843)

Age (mean (s.d.))

43.47 (10.59)

43.77 (10.20)

43.47 (10.59)

0.475

Age group (%)

 Young adults

31,591 (36.1)

204 (31.4)

31,387 (36.1)

0.006

 Middle-aged adults

50,542 (57.8)

415 (63.8)

50,127 (57.7)

 

 Older adults

5,360 (6.1)

31 (4.8)

5,329 (6.1)

 

Sex (%)

 Male

47,359 (54.1)

335 (51.5)

47,024 (54.1)

0.197

 Female

40,134 (45.9)

315 (48.5)

39,819 (45.9)

 

Drink (%)

 Yes

39,877 (45.6)

282 (43.4)

39,595 (45.6)

 

 No

46,593 (53.3)

359 (55.2)

46,234 (53.2)

0.489

 Unknown

1,023 (1.2)

9 (1.4)

1,014 (1.2)

 

Smoke (%)

 Yes

25,418 (29.1)

213 (32.8)

25,205 (29.0)

 

 No

60,916 (69.6)

429 (66.0)

60,487 (69.7)

0.111

 Unknown

1,159 (1.3)

8 (1.2)

1,151 (1.3)

 

Hypertension (%)

 Yes

6,499 (7.4)

64 (9.8)

6,435 (7.4)

 

 No

80,994 (92.6)

586 (90.2)

80,408 (92.6)

0.022

Diabetes (%)

 Yes

2,840 (3.2)

28 (4.3)

2,812 (3.2)

 

 No

84,653 (96.8)

622 (95.7)

84,031 (96.8)

0.155

Continuous variables (median (IQR))

 Red blood cell count (1012 l−1)

4.85 (4.48, 5.24)

4.82 (4.44, 5.24)

4.85 (4.48, 5.24)

0.261

 RDW-SD (fl)

44.10 (42.10, 46.40)

45.00 (42.60, 47.10)

44.10 (42.10, 46.40)

<0.001

 RDW-CV (%)

13.10 (12.50, 13.60)

13.20 (12.80, 13.80)

13.10 (12.50, 13.60)

<0.001

 Hematocrit (l l−1)

0.45 (0.42, 0.48)

0.44 (0.41, 0.48)

0.45 (0.42, 0.48)

0.371

 Mean corpuscular hemoglobin concentration (g l−1)

328.00 (321.00, 335.00)

329.00 (322.00, 336.00)

328.00 (321.00, 335.00)

0.020

 Mean corpuscular hemoglobin (pg)

30.50 (29.50, 31.50)

30.60 (29.50, 31.70)

30.50 (29.50, 31.50)

0.024

 Mean corpuscular volume (fl)

92.60 (89.80, 95.40)

92.90 (89.40, 95.50)

92.60 (89.80, 95.40)

0.546

 Hemoglobin (g l−1)

147.00 (135.00, 159.00)

147.00 (134.00, 160.00)

147.00 (135.00, 159.00)

0.954

 Equation K value of erythrocyte sedimentation rate

13.26 (9.84, 23.21)

13.91 (9.95, 26.66)

13.26 (9.84, 23.21)

0.103

 Erythrocyte sedimentation rate (mm h−1)

7.00 (3.00, 13.00)

6.00 (5.50, 6.50)

7.00 (3.00, 13.00)

0.802

 White blood cell count (109 l−1)

5.66 (4.81, 6.68)

5.70 (4.83, 6.79)

5.66 (4.81, 6.68)

0.522

 Neutrophil count (109 l−1)

3.31 (2.69, 4.07)

3.31 (2.71, 4.14)

3.31 (2.69, 4.07)

0.607

 Neutrophil percentage (%)

59.00 (53.60, 64.30)

59.20 (53.70, 64.00)

59.00 (53.60, 64.30)

0.971

 LymC (109 l−1)

1.72 (1.37, 2.11)

1.72 (1.36, 2.12)

1.72 (1.37, 2.11)

0.824

 Lymphocyte percentage (%)

31.70 (26.90, 36.80)

31.80 (27.30, 36.80)

31.70 (26.90, 36.80)

0.903

 Eosinophil count (109 l−1)

0.10 (0.06, 0.17)

0.10 (0.06, 0.18)

0.10 (0.06, 0.17)

0.079

 Eosinophil percentage (%)

1.80 (1.10, 2.90)

1.90 (1.10, 3.10)

1.80 (1.10, 2.90)

0.100

 Basophil count (109 l−1)

0.03 (0.02, 0.04)

0.03 (0.02, 0.04)

0.03 (0.02, 0.04)

0.071

 Basophil percentage (%)

0.50 (0.30, 0.70)

0.50 (0.30, 0.70)

0.50 (0.30, 0.70)

0.070

 Monocyte count (109 l−1)

0.35 (0.27, 0.43)

0.33 (0.27, 0.43)

0.35 (0.27, 0.43)

0.047

 Monocyte percentage (%)

6.10 (5.10, 7.20)

5.90 (5.00, 7.00)

6.10 (5.10, 7.20)

0.002

 CD3 count (cells μl−1)

1,131.00 (909.00, 1,407.00)

1,144.00 (927.50, 1,456.50)

1,131.00 (909.00, 1,407.00)

0.211

 CD3 percentage (%)

70.90 (64.90, 76.10)

71.30 (64.72, 76.50)

70.90 (64.90, 76.10)

0.883

 CD4 count (cells μl−1)

605.00 (477.00, 764.00)

644.00 (513.50, 811.50)

605.00 (477.00, 764.00)

0.025

 CD4 percentage (%)

37.70 (32.70, 43.10)

38.85 (33.32, 44.82)

37.70 (32.70, 43.00)

0.021

 CD8 count (cells μl−1)

406.00 (302.00, 542.00)

382.00 (293.00, 550.50)

406.00 (302.00, 542.00)

0.487

 CD8 percentage (%)

25.30 (20.60, 30.50)

23.35 (20.17, 28.52)

25.30 (20.60, 30.60)

0.009

 CD4/CD8 ratio

1.49 (1.13, 1.98)

1.67 (1.24, 2.05)

1.49 (1.13, 1.98)

0.003

 Blood platelet count (109 l−1)

206.00 (168.00, 248.00)

196.00 (161.00, 237.00)

206.00 (168.00, 248.00)

<0.001

 Platelet-to-lymphocyte ratio

118.64 (92.71, 152.38)

113.41 (88.33, 142.95)

118.71 (92.75, 152.46)

0.003

 MLR

0.20 (0.16, 0.26)

0.20 (0.16, 0.25)

0.20 (0.16, 0.26)

0.211

 NLR

1.92 (1.49, 2.52)

1.95 (1.50, 2.56)

1.92 (1.49, 2.52)

0.368

  1. Continuous variables are presented as median (IQR) and categorical variables as percentage (%). Two-sided P values for group comparisons were calculated using the Mann–Whitney U test for continuous variables and the χ² test for categorical variables. Young adults, aged 18–39 years; middle-aged adults, aged 40–59 years; older adults, aged ≥60; CV, coefficient of variation.
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