Table 3 Logistic regression analyses of associations between trajectories of blood cell biomarkers and depression risk

All

N

Depression (%)

RDW-CV

13,787

4.71

Stable (ref.)

Inverted U-shape

0.871 (0.570, 1.333)

0.526

0.820 (0.535, 1.256)

0.361

0.839 (0.547, 1.286)

0.420

0.853 (0.557, 1.309)

0.467

Mean corpuscular hemoglobin

Increasing (ref.)

Stable

1.224 (0.786, 1.907)

0.371

1.289 (0.826, 2.011)

0.263

1.264 (0.810, 1.974)

0.302

1.244 (0.797, 1.942)

0.337

Mean corpuscular hemoglobin concentration

U-shape (ref.)

Decreasing

1.234 (0.672, 2.267)

0.497

1.369 (0.744, 2.520)

0.312

1.322 (0.718, 2.436)

0.370

1.305 (0.708, 2.404)

0.394

Hematocrit

Increasing (ref.)

Stable

0.779 (0.658, 0.923)

0.004

1.049 (0.838, 1.313)

0.676

1.071 (0.855, 1.343)

0.550

1.083 (0.863, 1.359)

0.492

Neutrophil percentage

U-shape (ref.)

Stable

0.926 (0.653, 1.313)

0.665

0.918 (0.647, 1.302)

0.630

0.902 (0.635, 1.281)

0.564

0.893 (0.625, 1.275)

0.533

LymC

Inverted U-shape (ref.)

Stable

0.714 (0.469, 1.089)

0.118

0.686 (0.449, 1.046)

0.080

0.696 (0.456, 1.063)

0.093

0.694 (0.455, 1.061)

0.092

CD3 percentage

Decreasing (ref.)

Stable

1.197 (0.712, 2.014)

0.498

1.173 (0.694, 1.980)

0.551

1.086 (0.641, 1.840)

0.760

1.078 (0.636, 1.827)

0.781

CD4 percentage

U-shape (ref.)

Stable

2.824 (0.692, 11.524)

0.148

2.747 (0.673, 11.217)

0.159

2.557 (0.625, 10.461)

0.192

2.498 (0.610, 10.223)

0.203

MLR

U-shape (ref.)

Stable

0.652 (0.434, 0.978)

0.039

0.616 (0.410, 0.926)

0.020

0.628 (0.417, 0.944)

0.025

0.625 (0.415, 0.940)

0.024

NLR

Stable (ref.)

Inverted N-shape

1.494 (1.003, 2.227)

0.048

1.516 (1.016, 2.260)

0.041

1.478 (0.990, 2.205)

0.056

1.512 (1.013, 2.258)

0.043

Platelet-to-lymphocyte ratio

Stable (ref.)

U-shape

1.067 (0.631, 1.805)

0.808

1.109 (0.655, 1.878)

0.699

1.071 (0.632, 1.815)

0.798

1.076 (0.635, 1.824)

0.784

Blood platelet count

U-shape (ref.)

Stable

1.080 (0.669, 1.744)

0.752

1.126 (0.697, 1.820)

0.628

1.126 (0.696, 1.821)

0.629

1.114 (0.688, 1.802)

0.661

Male

N

Depression (%)

RDW-CV

8,309

4.03

Low–stable (ref.)

High–stable

0.912 (0.464, 1.791)

0.789

0.915 (0.466, 1.798)

0.797

0.931 (0.474, 1.831)

0.836

0.948 (0.482, 1.865)

0.878

Mean corpuscular hemoglobin

Low–stable (ref.)

High–stable

1.005 (0.529, 1.911)

0.987

1.000 (0.526–1.900)

0.999

0.971 (0.510–1.848)

0.929

0.956 (0.502–1.821)

0.892

Mean corpuscular hemoglobin concentration

U-shape (ref.)

Low–decreasing

2.436 (0.774, 7.668)

0.128

2.433 (0.773, 7.658)

0.128

2.308 (0.733, 7.270)

0.153

2.275 (0.722, 7.168)

0.160

Neutrophil percentage

U-shape (ref.)

Low–decreasing

1.149 (0.708, 1.864)

0.573

1.142 (0.704, 1.853)

0.590

1.119 (0.689, 1.817)

0.650

1.094 (0.673, 1.779)

0.717

LymC

N-shape (ref.)

Stable

0.605 (0.391, 0.937)

0.024

0.597 (0.385, 0.925)

0.021

0.611 (0.394, 0.948)

0.028

0.606 (0.391, 0.941)

0.026

CD4 percentage

Inverted N-shape (ref.)

Low– increasing

2.571 (0.353, 18.742)

0.351

2.583 (0.354, 18.832)

0.349

2.293 (0.313, 16.774)

0.414

2.307 (0.315, 16.888)

0.410

MLR

Stable (ref.)

U-shape

1.753 (1.073, 2.866)

0.025

1.764 (1.079, 2.884)

0.024

1.700 (1.038, 2.783)

0.035

1.714 (1.046, 2.807)

0.032

Platelet-to-lymphocyte ratio

Stable (ref.)

U-shape

1.003 (0.528, 1.907)

0.992

1.020 (0.536, 1.940)

0.953

0.981 (0.515, 1.868)

0.952

0.989 (0.519, 1.884)

0.973

Blood platelet count

U-shape (ref.)

Stable

1.025 (0.522, 2.015)

0.943

1.048 (0.532, 2.062)

0.892

1.053 (0.534, 2.074)

0.882

1.035 (0.525, 2.041)

0.921

Female

N

Depression (%)

RDW-CV

5,478

5.75

Stable (ref.)

Inverted U-shape

0.860 (0.505, 1.464)

0.577

0.867 (0.509, 1.476)

0.599

0.891 (0.523, 1.519)

0.672

0.900 (0.527, 1.537)

0.700

Mean corpuscular hemoglobin

U-shape (ref.)

Stable

1.266 (0.717, 2.236)

0.416

1.258 (0.712, 2.221)

0.430

1.252 (0.708, 2.214)

0.439

1.240 (0.700, 2.194)

0.461

Mean corpuscular hemoglobin concentration

U-shape (ref.)

Decreasing

1.122 (0.520, 2.423)

0.769

1.118 (0.518, 2.414)

0.776

1.092 (0.505, 2.361)

0.823

1.073 (0.496, 2.323)

0.858

Mean corpuscular volume

Low–increasing (ref.)

High–increasing

1.779 (0.871, 3.633)

0.114

1.768 (0.866, 3.610)

0.118

1.755 (0.858, 3.586)

0.123

1.715 (0.838, 3.508)

0.140

Hemoglobin

Increasing (ref.)

Stable

0.908 (0.440, 1.876)

0.795

0.903 (0.437, 1.865)

0.783

0.895 (0.433, 1.851)

0.765

0.877 (0.424, 1.815)

0.723

Hematocrit

Increasing (ref.)

Stable

1.249 (0.580, 2.690)

0.570

1.240 (0.575, 2.671)

0.583

1.224 (0.567, 2.640)

0.607

1.194 (0.553, 2.577)

0.652

Neutrophil percentage

Decreasing (ref.)

N-shape

1.533 (0.966, 2.434)

0.070

1.510 (0.950, 2.399)

0.082

1.527 (0.960, 2.429)

0.074

1.543 (0.958, 2.484)

0.074

Neutrophil count

U-shape (ref.)

Stable

1.083 (0.337, 3.485)

0.894

1.056 (0.328, 3.402)

0.927

1.042 (0.323, 3.361)

0.945

0.965 (0.299, 3.117)

0.952

LymC

N-shape (ref.)

Stable

0.785 (0.420, 1.465)

0.447

0.784 (0.420, 1.463)

0.444

0.786 (0.420, 1.469)

0.450

0.784 (0.419, 1.468)

0.447

CD3 percentage

Stable (ref.)

Decreasing

0.850 (0.386, 1.873)

0.688

0.834 (0.377, 1.844)

0.654

0.853 (0.385, 1.892)

0.696

0.851 (0.383, 1.894)

0.693

CD4 percentage

Stable (ref.)

U-shape

1.174 (0.355, 3.881)

0.792

1.173 (0.355, 3.877)

0.794

1.211 (0.365, 4.016)

0.754

1.320 (0.396, 4.397)

0.651

CD8 percentage

Stable (ref.)

U-shape

1.914 (0.661, 5.546)

0.232

1.877 (0.644, 5.468)

0.248

1.958 (0.670, 5.725)

0.220

2.041 (0.695, 5.996)

0.194

Blood platelet count

U-shape (ref.)

Stable

0.954 (0.538, 1.691)

0.872

0.968 (0.545, 1.717)

0.911

0.964 (0.543, 1.711)

0.899

0.964 (0.542, 1.714)

0.901