Fig. 3: Specificity analysis of the neurotoxicity assay.

Comparison of the IC10 for cytotoxicity and EC10 for neurite outgrowth inhibition in the neurotoxicity assay with differentiated neuronal cell line SH-SY5Y (Supplementary Table 12) with literature data of surface water during rain events (grey upward triangles) and WWTP effluent (grey downward triangles)38 and water (blue diamonds) and filter (green circles) extracts in the Oder River. The broken line indicates a specificity ratio SR of 1, the dotted line an SR of 10.