Abstract
Micro(nano)plastics (MNPs) are pervasive in global water sources, posing indirect threats to water quality by disrupting biogeochemical cycles, facilitating pathogen dispersion and interacting with emerging contaminants. Here we delve into the intricate ways in which MNPs affect nutrient sequestration, essential element adsorption and microbial functions, consequently impacting the carbon, nitrogen, phosphorus and sulfur cycles in aquatic environments. MNPs act as carriers for pathogens, potentially exacerbating transmission risks and endangering both aquatic ecosystems and human health. Moreover, their synergy with emerging contaminants amplifies contaminant persistence and bioavailability, warranting a deeper understanding of these implications for water security. We outline strategies for assessing the contributions of MNPs and implementing regulatory frameworks to mitigate their indirect effects. To manage these interactions under fluctuating environmental variables, advanced water treatment, modular control strategies, and early warning are essential. A holistic approach involving research, innovation and policy is imperative to protect water quality from MNPs-related impacts.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout






Similar content being viewed by others
References
Brahney, J. et al. Constraining the atmospheric limb of the plastic cycle. Proc. Natl Acad. Sci. USA 118, e2020719118 (2021).
Jambeck, J. R. et al. Plastic waste inputs from land into the ocean. Science 347, 768–771 (2015).
Allen, S. et al. Examination of the ocean as a source for atmospheric microplastics. PLoS ONE 15, e0232746 (2020).
Fuller, S. & Gautam, A. A procedure for measuring microplastics using pressurized fluid extraction. Environ. Sci. Technol. 50, 5774–5780 (2016).
Lebreton, L. C. M. et al. River plastic emissions to the world’s oceans. Nat. Commun. 8, 15611 (2017).
Li, J., Liu, H. & Paul Chen, J. Microplastics in freshwater systems: a review on occurrence, environmental effects and methods for microplastics detection. Water Res. 137, 362–374 (2018).
Zhou, Y. et al. Microplastics discharged from urban drainage system: prominent contribution of sewer overflow pollution. Water Res. 236, 119976 (2023).
Zhang, Q. et al. Distribution and sedimentation of microplastics in Taihu Lake. Sci. Total Environ. 795, 148745 (2021).
Niu, L. et al. Occurrence, degradation pathways and potential synergistic degradation mechanism of microplastics in surface water: a review. Curr. Pollut. Rep. 9, 312–326 (2023).
Collard, F., Gasperi, J., Gabrielsen, G. W. & Tassin, B. Plastic particle ingestion by wild freshwater fish: a critical review. Environ. Sci. Technol. 53, 12974–12988 (2019).
Lu, Y. et al. Uptake and accumulation of polystyrene microplastics in zebrafish (Danio rerio) and toxic effects in liver. Environ. Sci. Technol. 50, 4054–4060 (2016).
McIlwraith, H. K. et al. Evidence of microplastic translocation in wild-caught fish and implications for microplastic accumulation dynamics in food webs. Environ. Sci. Technol. 55, 12372–12382 (2021).
Bowley, J., Baker-Austin, C., Porter, A., Hartnell, R. & Lewis, C. Oceanic hitchhikers–assessing pathogen risks from marine microplastic. Trends Microbiol. 29, 107–116 (2021).
Law, K. L. & Thompson, R. C. Microplastics in the seas. Science 345, 144–145 (2014).
Romera-Castillo, C., Pinto, M., Langer, T. M., Álvarez-Salgado, X. A. & Herndl, G. J. Dissolved organic carbon leaching from plastics stimulates microbial activity in the ocean. Nat. Commun. 9, 1430 (2018).
Amaneesh, C. et al. Gross negligence: impacts of microplastics and plastic leachates on phytoplankton community and ecosystem dynamics. Environ. Sci. Technol. 57, 5–24 (2023).
Yang, X. et al. Microplastics and chemical leachates from plastic pipes are associated with increased virulence and antimicrobial resistance potential of drinking water microbial communities. J. Hazard. Mater. 463, 132900 (2024).
Fernández-Juárez, V. et al. ‘The good, the bad and the double-sword’ effects of microplastics and their organic additives in marine bacteria. Front. Microbiol. 11, 581118 (2021).
Gigault, J. et al. Nanoplastics are neither microplastics nor engineered nanoparticles. Nat. Nanotechnol. 16, 501–507 (2021).
Chen, X., Yu, X., Zhang, L., Zhao, W. & Sui, Q. Organic pollutants adsorbed on microplastics: potential indicators for source appointment of microplastics. J. Hazard. Mater. 465, 133225 (2024).
Cortés-Arriagada, D., Miranda-Rojas, S., Camarada, M. B., Ortega, D. E. & Alarcón-Palacio, V. B. The interaction mechanism of polystyrene microplastics with pharmaceuticals and personal care products. Sci. Total Environ. 861, 160632 (2023).
Yang, X. et al. Plastic particles affect N2O release via altering core microbial metabolisms in constructed wetlands. Water Res. 255, 121506 (2024).
Huang, X. et al. C-N-S synergy in a pilot-scale mainstream anammox fluidized-bed membrane bioreactor for treating chemically enhanced primary treatment saline sewage. Water Res. 229, 119475 (2023).
Sun, S., Hu, X., Kang, W. & Yao, M. Combined effects of microplastics and warming enhance algal carbon and nitrogen storage. Water Res. 233, 119815 (2023). This study provides insights into how microplastic pollution and warming can jointly reshape phytoplankton metabolism and affect biogeochemical cycling in aquatic ecosystems.
Yu, H. et al. Polyethylene microplastics interfere with the nutrient cycle in water-plant-sediment systems. Water Res. 214, 118191 (2022).
Hitchcock, J. N. Microplastics can alter phytoplankton community composition. Sci. Total Environ. 819, 153074 (2022).
Wang, X., Li, J. & Pan, X. How micro-/nano-plastics influence the horizontal transfer of antibiotic resistance genes—a review. Sci. Total Environ. 944, 173881 (2024).
Wu, L., Dong, J., Shen, Z. & Zhou, Y. Microplastics as vectors for antibiotic resistance: role of pathogens, heavy metals, and pharmaceuticals and personal care products. J. Water Process. Eng. 67, 106124 (2024).
Hu, X., Waigi, M. G., Yang, B. & Gao, Y. Impact of plastic particles on the horizontal transfer of antibiotic resistance genes to bacterium: dependent on particle sizes and antibiotic resistance gene vector replication capacities. Environ. Sci. Technol. 56, 14948–14959 (2022). This study highlights the complex and size-dependent role of plastic particles in facilitating or hindering ARG transfer.
Zhi, L., Li, Z., Su, Z. & Wang, J. Immunotoxicity of microplastics: carrying pathogens and destroying the immune system. TrAC Trends Anal. Chem. 177, 117817 (2024).
Zhong, H. et al. The hidden risk of microplastic-associated pathogens in aquatic environments. Eco Environ. Health 2, 142–151 (2023).
Liu, S. et al. Genome-wide molecular adaptation in algal primary productivity induced by prolonged exposure to environmentally realistic concentration of nanoplastics. Environ. Sci. Technol. 18, 29820–29831 (2024).
Loiseau, C. & Sorci, G. Can microplastics facilitate the emergence of infectious diseases? Sci. Total Environ. 823, 153694 (2022).
Wang, L. et al. Bacterial community colonization on tire microplastics in typical urban water environments and associated impacting factors. Environ. Pollut. 265, 114922 (2020).
Rochman, C. M. Microplastics research—from sink to source. Science 360, 28–29 (2018).
Nava, V. et al. Plastic debris in lakes and reservoirs. Nature 619, 317–322 (2023).
Vethaak, A. D. & Legler, J. Microplastics and human health. Science 371, 672–674 (2021).
Mitrano, D. M., Wick, P. & Nowack, B. Placing nanoplastics in the context of global plastic pollution. Nat. Nanotechnol. 16, 491–500 (2021).
Su, X. et al. Estuarine plastisphere as an overlooked source of N2O production. Nat. Commun. 13, 3884 (2022). This study pinpoints plastisphere as a N2O source, and provides insights into roles of the new biotope in biogeochemical cycling in the Anthropocene.
Gong, M., Yang, G., Zhuang, L. & Zeng, E. Y. Microbial biofilm formation and community structure on low-density polyethylene microparticles in lake water microcosms. Environ. Pollut. 252, 94–102 (2019).
Bank, M. S., Mitrano, D. M., Rillig, M. C., Sze Ki Lin, C. & Ok, Y. S. Embrace complexity to understand microplastic pollution. Nat. Rev. Earth Environ. 3, 736–737 (2022).
Zhou, J., Gao, L., Lin, Y., Pan, B. & Li, M. Micrometer scale polystyrene plastics of varying concentrations and particle sizes inhibit growth and upregulate microcystin-related gene expression in Microcystis aeruginosa. J. Hazard. Mater. 420, 126591 (2021).
Gall, S. C. & Thompson, R. C. The impact of debris on marine life. Mar. Pollut. Bull. 92, 170–179 (2015).
Parrella, F., Brizzolara, S., Holzner, M. & Mitrano, D. M. Impact of heteroaggregation between microplastics and algae on particle vertical transport. Nat. Water 2, 541–552 (2024).
Mato, Y. et al. Plastic resin pellets as a transport medium for toxic chemicals in the marine environment. Environ. Sci. Technol. 35, 318–324 (2001).
Amaral-Zettler, L. A., Zettler, E. R. & Mincer, T. J. Ecology of the plastisphere. Nat. Rev. Microbiol. 18, 139–151 (2020).
Zettler, E. R., Mincer, T. J. & Amaral-Zettler, L. A. Life in the ‘plastisphere’: microbial communities on plastic marine debris. Environ. Sci. Technol. 47, 7137–7146 (2013).
Xu, C., Lu, J., Shen, C., Wang, J. & Li, F. Deciphering the mechanisms shaping the plastisphere antibiotic resistome on riverine microplastics. Water Res. 225, 119192 (2022).
Miao, L. et al. Distinct microbial metabolic activities of biofilms colonizing microplastics in three freshwater ecosystems. J. Hazard. Mater. 403, 123577 (2021).
Zheng, X. et al. Toxicity mechanism of Nylon microplastics on Microcystis aeruginosa through three pathways: photosynthesis, oxidative stress and energy metabolism. J. Hazard. Mater. 426, 128094 (2022).
Kesy, K., Oberbeckmann, S., Kreikemeyer, B. & Labrenz, M. Spatial environmental heterogeneity determines young biofilm assemblages on microplastics in Baltic Sea mesocosms. Front. Microbiol. 10, 1665 (2019).
Chen, Y. et al. Effects of microplastics on soil carbon pool and terrestrial plant performance. Carbon Res. 3, 37 (2024).
Abbasi, S. Uncovering the intricate relationship between plant nutrients and microplastics in agroecosystems. Chemosphere 346, 140604 (2024).
Webb, H. K., Crawford, R. J., Sawabe, T. & Ivanova, E. P. Poly(ethylene terephthalate) polymer surfaces as a substrate for bacterial attachment and biofilm formation. Microbes Environ. 24, 39–42 (2009).
Galloway, T. S., Cole, M. & Lewis, C. Interactions of microplastic debris throughout the marine ecosystem. Nat. Ecol. Evol. 1, 116 (2017).
Li, Y. et al. Interactions between nano/micro plastics and suspended sediment in water: implications on aggregation and settling. Water Res. 161, 486–495 (2019).
He, B., Duodu, G. O., Rintoul, L., Ayoko, G. A. & Goonetilleke, A. Influence of microplastics on nutrients and metal concentrations in river sediments. Environ. Pollut. 263, 114490 (2020).
Wang, H., Huang, W., Zhang, Y., Wang, C. & Jiang, H. Unique metalloid uptake on microplastics: the interaction between boron and microplastics in aquatic environment. Sci. Total Environ. 800, 149668 (2021).
Zhao, M. et al. Adsorption of different pollutants by using microplastic with different influencing factors and mechanisms in wastewater: a review. Nanomaterials (Basel) 12, 2256 (2022).
Fadare, O. O. et al. Eco-corona vs protein corona: effects of humic substances on corona formation and nanoplastic particle toxicity in Daphnia magna. Environ. Sci. Technol. 54, 8001–8009 (2020).
Kang, W., Sun, S. & Hu, X. Microplastics trigger the Matthew effect on nitrogen assimilation in marine diatoms at an environmentally relevant concentration. Water Res. 233, 119762 (2023).
Yin, M. et al. Effects of microplastics on nitrogen and phosphorus cycles and microbial communities in sediments. Environ. Pollut. 318, 120852 (2023).
Khan, T. F. & Hodson, M. E. Polyethylene microplastic can adsorb phosphate but is unlikely to limit its availability in soil. Heliyon 10, e23179 (2024).
Dai, H.-H., Gao, J.-F., Wang, Z.-Q., Zhao, Y.-F. & Zhang, D. Behavior of nitrogen, phosphorus and antibiotic resistance genes under polyvinyl chloride microplastics pressures in an aerobic granular sludge system. J. Clean. Prod. 256, 120402 (2020).
Ahmad, M. et al. Microplastic-assisted removal of phosphorus and ammonium using date palm waste derived biochar. Toxics 11, 881 (2023).
Song, X. et al. New insights into changes in phosphorus profile at sediment-water interface by microplastics: role of benthic bioturbation. J. Hazard. Mater. 469, 134047 (2024). This study finds that microplastics alter phosphorus biogeochemical processes by disrupting the bioturbation activities of chironomid larvae.
Casals, E., Pfaller, T., Duschl, A., Oostingh, G. J. & Puntes, V. Time evolution of the nanoparticle protein corona. ACS Nano 4, 3623–3632 (2010).
Ali, I. et al. Eco- and bio-corona-based microplastics and nanoplastics complexes in the environment: modulations in the toxicological behavior of plastic particles and factors affecting. Process Saf. Environ. Prot. 187, 356–375 (2024).
Cao, J. et al. Coronas of micro/nano plastics: a key determinant in their risk assessments. Part. Fibre Toxicol. 19, 55 (2022).
Liu, G., Jiang, R., You, J., Muir, D. C. G. & Zeng, E. Y. Microplastic impacts on microalgae growth: effects of size and humic acid. Environ. Sci. Technol. 54, 1782–1789 (2020).
Parsai, T. et al. Implication of microplastic toxicity on functioning of microalgae in aquatic system. Environ. Pollut. 308, 119626 (2022).
Lagarde, F. et al. Microplastic interactions with freshwater microalgae: hetero-aggregation and changes in plastic density appear strongly dependent on polymer type. Environ. Pollut. 215, 331–339 (2016).
Coppock, R. L. et al. Microplastics alter feeding selectivity and faecal density in the copepod, Calanus helgolandicus. Sci. Total Environ. 687, 780–789 (2019).
Wieczorek, A. M., Croot, P. L., Lombard, F., Sheahan, J. N. & Doyle, T. K. Microplastic ingestion by gelatinous zooplankton may lower efficiency of the biological pump. Environ. Sci. Technol. 53, 5387–5395 (2019).
Paluselli, A., Fauvelle, V., Galgani, F. & Sempéré, R. Phthalate release from plastic fragments and degradation in seawater. Environ. Sci. Technol. 53, 166–175 (2019).
Yang, X. et al. Nanoplastics disturb nitrogen removal in constructed wetlands: responses of microbes and macrophytes. Environ. Sci. Technol. 54, 14007–14016 (2020).
Li, Y. et al. Current advances in microplastic contamination in aquatic sediment: analytical methods, global occurrence and effects on elemental cycling. TrAC Trends Anal. Chem. 168, 117331 (2023).
Liu, S. et al. Differences of microplastics and nanoplastics in urban waters: environmental behaviors, hazards and removal. Water Res. 260, 121895 (2024).
Wu, T. et al. Microplastics perturb nitrogen removal, microbial community and metabolism mechanism in biofilm system. J. Hazard. Mater. 458, 131971 (2023).
Seeley, M. E., Song, B., Passie, R. & Hale, R. C. Microplastics affect sedimentary microbial communities and nitrogen cycling. Nat. Commun. 11, 2372 (2020).
Su, X. et al. Nitrifying niche in estuaries is expanded by the plastisphere. Nat. Commun. 15, 5866 (2024).
He, Y. et al. Insights into N2O turnovers under polyethylene terephthalate microplastics stress in mainstream biological nitrogen removal process. Water Res. 224, 119037 (2022).
Long, M. et al. Interactions between microplastics and phytoplankton aggregates: impact on their respective fates. Mar. Chem. 175, 39–46 (2015).
Wang, H. et al. Coupling of sulfate reduction and dissolved organic carbon degradation accelerated by microplastics in blue carbon ecosystems. Water Res. 279, 123414 (2025). This study provides the first evidence that PLA microplastics significantly enhance the activity of microorganisms driving carbon and sulfur cycling.
Zhang, H., Quan, H., Zhou, S., Sun, L. & Lu, H. Enhanced performance and electron transfer of sulfur-mediated biological process under polyethylene terephthalate microplastics exposure. Water Res. 223, 119038 (2022).
Pinnell, L. J. & Turner, J. W. Shotgun metagenomics reveals the benthic microbial community response to plastic and bioplastic in a coastal marine environment. Front. Microbiol. 10, 1252 (2019).
Rahman, I., Mujahid, A., Palombo, E. A. & Müller, M. A functional gene-array analysis of microbial communities settling on microplastics in a peat-draining environment. Mar. Pollut. Bull. 166, 112226 (2021).
Wang, H. et al. Stable isotopic and metagenomic analyses reveal microbial-mediated effects of microplastics on sulfur cycling in coastal sediments. Environ. Sci. Technol. 57, 1167–1176 (2023).
Chen, C. et al. Effects of microplastics on denitrification and associated N2O emission in estuarine and coastal sediments: insights from interactions between sulfate reducers and denitrifiers. Water Res. 245, 120590 (2023).
Chen, X. et al. Effects of microplastic biofilms on nutrient cycling in simulated freshwater systems. Sci. Total Environ. 719, 137276 (2020).
Wang, X. et al. Recent advances on the effects of microplastics on elements cycling in the environment. Sci. Total Environ. 849, 157884 (2022).
Song, X., Zou, H., Zhang, Y., Yang, J. & Ding, J. Microplastics alter the microbiota-mediated phosphorus profiles at sediment-water interface: distinct microbial effects between sediment and plastisphere. Sci. Total Environ. 933, 173048 (2024).
Sanz-Lázaro, C., Casado-Coy, N. & Beltrán-Sanahuja, A. Biodegradable plastics can alter carbon and nitrogen cycles to a greater extent than conventional plastics in marine sediment. Sci. Total Environ. 756, 143978 (2021).
Yang, M., Zhang, B., Xin, X., Lee, K. & Chen, B. Microplastic and oil pollution in oceans: interactions and environmental impacts. Sci. Total Environ. 838, 156142 (2022).
Zhang, Y. et al. How climate change and eutrophication interact with microplastic pollution and sediment resuspension in shallow lakes: a review. Sci. Total Environ. 705, 135979 (2020).
Ma, Y. et al. A comprehensive study on the exposure of nanoplastics to constructed wetland ecological systems: macrophyte physiology and microbial enzymology, community composition and metabolic functions. Chem. Eng. J. 434, 134592 (2022).
Oberbeckmann, S., Kreikemeyer, B. & Labrenz, M. Environmental factors support the formation of specific bacterial assemblages on microplastics. Front. Microbiol. 8, 2709 (2018).
Guo, X. & Wang, J. The chemical behaviors of microplastics in marine environment: a review. Mar. Pollut. Bull. 142, 1–14 (2019).
Li, R. et al. Viral metagenome reveals microbial hosts and the associated antibiotic resistome on microplastics. Nat. Water 2, 553–565 (2024). This study provides comprehensive profiles of viral communities, virus-related ARGs and their driving factors on microplastics.
McCormick, A. R. et al. Microplastic in surface waters of urban rivers: concentration, sources and associated bacterial assemblages. Ecosphere 7, e01556 (2016).
Bydalek, F. et al. Microplastic biofilm, associated pathogen and antimicrobial resistance dynamics through a wastewater treatment process incorporating a constructed wetland. Water Res. 235, 119936 (2023).
Zhang, Y., Lu, J., Wu, J., Wang, J. & Luo, Y. Potential risks of microplastics combined with superbugs: enrichment of antibiotic resistant bacteria on the surface of microplastics in mariculture system. Ecotoxicol. Environ. Saf. 187, 109852 (2020).
Marti, E., Variatza, E. & Balcazar, J. L. The role of aquatic ecosystems as reservoirs of antibiotic resistance. Trends Microbiol. 22, 36–41 (2014).
Li, Y. et al. Engineered DNA scavenger for mitigating antibiotic resistance proliferation in wastewater treatment. Nat. Water 2, 758–769 (2024).
Ramírez-Castillo, F. Y. et al. Waterborne pathogens: detection methods and challenges. Pathogens 4, 307–334 (2015).
Kettner, M. T., Oberbeckmann, S., Labrenz, M. & Grossart, H.-P. The eukaryotic life on microplastics in brackish ecosystems. Front. Microbiol. 10, 538 (2019).
McCormick, A., Hoellein, T. J., Mason, S. A., Schluep, J. & Kelly, J. J. Microplastic is an abundant and distinct microbial habitat in an urban river. Environ. Sci. Technol. 48, 11863–11871 (2014).
Casabianca, S. et al. Plastic-associated harmful microalgal assemblages in marine environment. Environ. Pollut. 244, 617–626 (2019).
Li, R., Zhu, L., Cui, L. & Zhu, Y.-G. Viral diversity and potential environmental risk in microplastic at watershed scale: evidence from metagenomic analysis of plastisphere. Environ. Int. 161, 107146 (2022).
Shruti, V. C., Kutralam-Muniasamy, G. & Perez-Guevara, F. Viruses in the era of microplastics and plastispheres: analytical methods, advances and future directions. Sci. Total Environ. 955, 177010 (2024).
Yi, X. et al. Giant viruses as reservoirs of antibiotic resistance genes. Nat. Commun. 15, 7536 (2024).
Rai, P. K., Sonne, C., Brown, R. J. C., Younis, S. A. & Kim, K.-H. Adsorption of environmental contaminants on micro- and nano-scale plastic polymers and the influence of weathering processes on their adsorptive attributes. J. Hazard. Mater. 427, 127903 (2022).
Rillig, M. C. & Lehmann, A. Microplastic in terrestrial ecosystems. Science 368, 1430–1431 (2020).
Lu, J., Yu, Z., Ngiam, L. & Guo, J. Microplastics as potential carriers of viruses could prolong virus survival and infectivity. Water Res. 225, 119115 (2022).
He, L. et al. Bacteria have different effects on the transport behaviors of positively and negatively charged microplastics in porous media. J. Hazard. Mater. 415, 125550 (2021).
Thompson, J. R. et al. Diversity and dynamics of a North Atlantic coastal Vibrio community. Appl. Environ. Microbiol. 70, 4103–4110 (2004).
He, S. et al. Microplastics influence the fate of antibiotics in freshwater environments: biofilm formation and its effect on adsorption behavior. J. Hazard. Mater. 442, 130078 (2023).
Zhang, W. et al. Physiological characteristics, geochemical properties and hydrological variables influencing pathogen migration in subsurface system: what we know or not? Geosci. Front. 13, 101346 (2022).
Zhang, Y., Cai, Y., Zhang, B. & Zhang, Y.-H. P. J. Spatially structured exchange of metabolites enhances bacterial survival and resilience in biofilms. Nat. Commun. 15, 7575 (2024).
Yin, W., Wang, Y., Liu, L. & He, J. Biofilms: the microbial ‘protective clothing’ in extreme environments. Int. J. Mol. Sci. 20, 3423 (2019).
Wu, J. et al. Phthalates promote dissemination of antibiotic resistance genes: an overlooked environmental risk. Environ. Sci. Technol. 57, 6876–6887 (2023).
Luo, T., Dai, X., Wei, W., Xu, Q. & Ni, B.-J. Microplastics enhance the prevalence of antibiotic resistance genes in anaerobic sludge digestion by enriching antibiotic-resistant bacteria in surface biofilm and facilitating the vertical and horizontal gene transfer. Environ. Sci. Technol. 57, 14611–14621 (2023).
Huang, Y. et al. Coupled effects of urbanization level and dam on microplastics in surface waters in a coastal watershed of Southeast China. Mar. Pollut. Bull. 154, 111089 (2020).
Watkins, L., McGrattan, S., Sullivan, P. J. & Walter, M. T. The effect of dams on river transport of microplastic pollution. Sci. Total Environ. 664, 834–840 (2019).
Beans, C. Are microplastics spreading infectious disease? Proc. Natl Acad. Sci. USA 120, e2311253120 (2023).
Chowdhury, B. & Anand, S. Environmental persistence of Listeria monocytogenes and its implications in dairy processing plants. Compr. Rev. Food Sci. Food Saf. 22, 4573–4599 (2023).
Wang, X. et al. Microplastic-mediated new mechanism of liver damage: from the perspective of the gut–liver axis. Sci. Total Environ. 919, 170962 (2024).
Nguyen, T. B.-A. et al. Protistan predation selects for antibiotic resistance in soil bacterial communities. ISME J. 17, 2182–2189 (2023).
McDougall, L. et al. Adsorption of a diverse range of pharmaceuticals to polyethylene microplastics in wastewater and their desorption in environmental matrices. Sci. Total Environ. 808, 152071 (2022).
Atugoda, T. et al. Interactions between microplastics, pharmaceuticals and personal care products: implications for vector transport. Environ. Int. 149, 106367 (2021).
Li, J., Zhang, K. & Zhang, H. Adsorption of antibiotics on microplastics. Environ. Pollut. 237, 460–467 (2018).
Liu, G. et al. Sorption behavior and mechanism of hydrophilic organic chemicals to virgin and aged microplastics in freshwater and seawater. Environ. Pollut. 246, 26–33 (2019).
Wang, F. et al. Interaction of toxic chemicals with microplastics: a critical review. Water Res. 139, 208–219 (2018).
Bhagat, J., Nishimura, N. & Shimada, Y. Toxicological interactions of microplastics/nanoplastics and environmental contaminants: current knowledge and future perspectives. J. Hazard. Mater. 405, 123913 (2021).
Santana-Viera, S., Montesdeoca-Esponda, S., Torres-Padrón, M. E., Sosa-Ferrera, Z. & Santana-Rodríguez, J. J. An assessment of the concentration of pharmaceuticals adsorbed on microplastics. Chemosphere 266, 129007 (2021).
Yu, Y., Mo, W. Y. & Luukkonen, T. Adsorption behaviour and interaction of organic micropollutants with nano and microplastics – a review. Sci. Total Environ. 797, 149140 (2021).
Frias, J. P. G. L., Sobral, P. & Ferreira, A. M. Organic pollutants in microplastics from two beaches of the Portuguese coast. Mar. Pollut. Bull. 60, 1988–1992 (2010).
Rochman, C. M. et al. Polybrominated diphenyl ethers (PBDEs) in fish tissue may be an indicator of plastic contamination in marine habitats. Sci. Total Environ. 476-477, 622–633 (2014).
Hirai, H. et al. Organic micropollutants in marine plastics debris from the open ocean and remote and urban beaches. Mar. Pollut. Bull. 62, 1683–1692 (2011).
Zhang, W. et al. Persistent organic pollutants carried on plastic resin pellets from two beaches in China. Mar. Pollut. Bull. 99, 28–34 (2015).
Ding, L., Mao, R., Ma, S., Guo, X. & Zhu, L. High temperature depended on the ageing mechanism of microplastics under different environmental conditions and its effect on the distribution of organic pollutants. Water Res. 174, 115634 (2020).
Liu, P. et al. New insights into the aging behavior of microplastics accelerated by advanced oxidation processes. Environ. Sci. Technol. 53, 3579–3588 (2019).
Xiang, Y. et al. Carbon-based materials as adsorbent for antibiotics removal: mechanisms and influencing factors. J. Environ. Manag. 237, 128–138 (2019).
Antony, A., Fudianto, R., Cox, S. & Leslie, G. Assessing the oxidative degradation of polyamide reverse osmosis membrane—Accelerated ageing with hypochlorite exposure. J. Membr. Sci. 347, 159–164 (2010).
Yu, F., Yang, C., Zhu, Z., Bai, X. & Ma, J. Adsorption behavior of organic pollutants and metals on micro/nanoplastics in the aquatic environment. Sci. Total Environ. 694, 133643 (2019).
Wu, P., Cai, Z., Jin, H. & Tang, Y. Adsorption mechanisms of five bisphenol analogues on PVC microplastics. Sci. Total Environ. 650, 671–678 (2019).
Hüffer, T. & Hofmann, T. Sorption of non-polar organic compounds by micro-sized plastic particles in aqueous solution. Environ. Pollut. 214, 194–201 (2016).
Chen, Y., Li, J., Wang, F., Yang, H. & Liu, L. Adsorption of tetracyclines onto polyethylene microplastics: a combined study of experiment and molecular dynamics simulation. Chemosphere 265, 129133 (2021).
Lu, H.-C., Ziajahromi, S., Locke, A., Neale, P. A. & Leusch, F. D. L. Microplastics profile in constructed wetlands: distribution, retention and implications. Environ. Pollut. 313, 120079 (2022).
Shen, M. et al. Microplastics act as an important protective umbrella for bacteria during water/wastewater disinfection. J. Clean. Prod. 315, 128188 (2021).
Nguyen, H. T., Lee, Y. K., Kwon, J. H. & Hur, J. Microplastic biofilms in water treatment systems: fate and risks of pathogenic bacteria, antibiotic-resistant bacteria, and antibiotic resistance genes. Sci. Total Environ. 892, 164523 (2023).
Seewoo, B. J. et al. How do plastics, including microplastics and plastic-associated chemicals, affect human health? Nat. Med. 30, 3036–3037 (2024).
Ramsperger, A. F. R. M. et al. Environmental exposure enhances the internalization of microplastic particles into cells. Sci. Adv. 6, eabd1211 (2020). This study finds that the coating of the particles with biomolecules enhances the cellular internalization of microplastic particles.
Samir, A., Ashour, F. H., Hakim, A. A. A. & Bassyouni, M. Recent advances in biodegradable polymers for sustainable applications. npj Mater. Degrad. 6, 68 (2022).
Kaing, V. et al. Photodegradation of biodegradable plastics in aquatic environments: current understanding and challenges. Sci. Total Environ. 911, 168539 (2024).
DelRe, C. et al. Near-complete depolymerization of polyesters with nano-dispersed enzymes. Nature 592, 558–563 (2021).
Guicherd, M. et al. An engineered enzyme embedded into PLA to make self-biodegradable plastic. Nature 631, 884–890 (2024). This study presents a PLA-based plastic in which an optimized enzyme is embedded to ensure rapid biodegradation and compostability at room temperature, using a scalable industrial process.
Yu, F., Qin, Q., Zhang, X. & Ma, J. Characteristics and adsorption behavior of typical microplastics in long-term accelerated weathering simulation. Environ. Sci. Process. Impacts 26, 882–890 (2024).
Ashok, D. et al. Superhydrophobic surfaces to combat bacterial surface colonization. Adv. Mater. Interfaces 10, 2300324 (2023).
Jin, H., Kong, F., Li, X. & Shen, J. Artificial intelligence in microplastic detection and pollution control. Environ. Res. 262, 119812 (2024).
Mu, M. et al. Multifunctional coatings for mitigating bacterial fouling and contamination. Colloids Interface Sci. Commun. 55, 100717 (2023).
Ali, I. et al. Removal of micro- and nanoplastics by filtration technology: performance and obstructions to market penetrations. J. Clean. Prod. 470, 143305 (2024).
Lu, Y., Li, M.-C., Lee, J., Liu, C. & Mei, C. Microplastic remediation technologies in water and wastewater treatment processes: current status and future perspectives. Sci. Total Environ. 868, 161618 (2023).
Mehta, N. et al. Advances in circular bioeconomy technologies: from agricultural wastewater to value-added resources. Environments 8, 20 (2021).
Maneein, S., Sangsanont, J., Limpiyakorn, T., Sirikanchana, K. & Rattanakul, S. The coagulation process for enveloped and non-enveloped virus removal in turbid water: removal efficiencies, mechanisms and its application to SARS-CoV-2 Omicron BA.2. Sci. Total Environ. 931, 172945 (2024).
Jiao, Y. et al. Adsorption efficiency and in-situ catalytic thermal degradation behaviour of microplastics from water over Fe-modified lignin-based magnetic biochar. Sep. Purif. Technol. 353, 128468 (2025).
Ali, I. et al. Innovations in the development of promising adsorbents for the remediation of microplastics and nanoplastics—a critical review. Water Res. 230, 119526 (2023).
Jia, M. et al. Advanced nanobubble flotation for enhanced removal of sub-10-µm microplastics from wastewater. Nat. Commun. 15, 9079 (2024).
Liu, S. et al. Removal of micro/nanoplastics in constructed wetland: efficiency, limitations and perspectives. Chem. Eng. J. 475, 146033 (2023).
Li, C. et al. A low-impact nature-based solution for reducing aquatic microplastics from freshwater ecosystems. Water Res. 268, 122632 (2025). This work provides the first evidence-based demonstration of a low-impact, plant-based solution capable of simultaneously removing microplastics and nutrients from freshwater ecosystems.
Yuan, W. et al. Tracing and trapping micro- and nanoplastics: untapped mitigation potential of aquatic plants? Water Res. 242, 120249 (2023).
Siddall, R. et al. The Natural Robotics Contest: crowdsourced biomimetic design. Bioinspir. Biomim. 18, 036002 (2023).
Leppänen, I. et al. Capturing colloidal nano- and microplastics with plant-based nanocellulose networks. Nat. Commun. 13, 1814 (2022).
Wang, Y. et al. Flowthrough capture of microplastics through polyphenol-mediated interfacial interactions on wood sawdust. Adv. Mater. 35, 2301531 (2023).
Özgenç, E. Advanced analytical techniques for assessing and detecting microplastic pollution in water and wastewater systems. Environ. Qual. Manag. 34, e22217 (2024).
Berkel, C. & Özbek, O. Methods used in the identification and quantification of micro(nano)plastics from water environments. S. Afr. J. Chem. Eng. 50, 388–403 (2024).
Zendehboudi, S., Rezaei, N. & Lohi, A. Applications of hybrid models in chemical, petroleum and energy systems: a systematic review. Appl. Energy 228, 2539–2566 (2018).
Beghetto, V. et al. Plastics today: key challenges and EU strategies towards carbon neutrality: a review. Environ. Pollut. 334, 122102 (2023).
Mitrano, D. M. & Wohlleben, W. Microplastic regulation should be more precise to incentivize both innovation and environmental safety. Nat. Commun. 11, 5324 (2020).
Abdolahpur Monikh, F. et al. Exposure protocol for ecotoxicity testing of microplastics and nanoplastics. Nat. Protoc. 18, 3534–3564 (2023).
Ladewig, S. M., Coco, G., Hope, J. A., Vieillard, A. M. & Thrush, S. F. Real-world impacts of microplastic pollution on seafloor ecosystem function. Sci. Total Environ. 858, 160114 (2023).
Liu, X. et al. Microplastic diversity stimulates N2O emission during NO3−-N transformation by altering microbial interaction and electron consumption in eutrophic water. J. Hazard. Mater. 489, 137594 (2025).
Acknowledgements
This work is supported by the Australian Research Council (ARC) Discovery Project (DP220101139) and Linkage Project (LP240100542). W.W. acknowledges the support of the ARC through project no. DE220100530.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Peer review
Peer review information
Nature Water thanks Austin Gray and Jie Ma for their contribution to the peer review of this work.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Liu, X., Wei, W., Chen, Z. et al. The threats of micro- and nanoplastics to aquatic ecosystems and water health. Nat Water 3, 764–781 (2025). https://doi.org/10.1038/s44221-025-00464-1
Received:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/s44221-025-00464-1