Table 2 Gentamicin MIC against P. aeruginosa strains PA7 and PA14 in the absence and presence of berberine or select analogs.

From: Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition

Strain

Gentamicin MIC, µg/mL (fold change)a,b,c

–

Berberine

Ber-C3 [5]

Ber-C12 [9]

Ber-pAr [10]

PAO1

1

0.5 (2)

0.25 (4)

0.125 (8)

0.25 (4)

PA7

256

128/64 (2/4)

32 (8)

32 (8)

64 (4)

PA14

2

2/1 (−/2)

1 (2)

1 (2)

2/1 (−/2)

  1. aBerberine or analog included at 64 µg/mL.
  2. bMIC data for PAO1 are the same as in Supplementary Table 4 and are shown for ease of comparison.
  3. cFold change is relative to respective to wild-type PAO1, PA7, or PA14, (−) represents no fold change.
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