Fig. 1: Time course simulations of farm flow model where resistance is plasmid-encoded.

a Time course simulation showing the concentration of bacterial populations across different areas of the farm over 365 days, using parameter values gathered from farm data (Supplementary Tables 1–6). Resistance genes to oxytetracycline, cefalexin, copper and zinc are assumed to be encoded on plasmids and may be transferred horizontally between populations. Copper resistance is very similar to zinc resistance and so is not visible. b The same simulation, plotting the proportions of each sub-population (sensitive, Cu-, Zn-, Oxy- and Cex-resistant bacteria).