Table 2 MIC data for the lead PBD compounds KMR-14-03, KMR-14-14, KMR-14-33, and PP-A148 against the wildtype K. pneumoniae MKP103 strain and a MKP103 strain containing a transposon insertion in its tsx gene

From: Convergent evolution of antibiotic resistance mechanisms between pyrrolobenzodiazepines and albicidin in multidrug resistant Klebsiella pneumoniae

 

MIC (μg/mL)

Strain

KMR-14-03

KMR-14-14

KMR-14-33

PP-A148

MKP103 WT

16

4

8–16

32

MKP103 Tn:tsx

>32

>32

>32

128

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