Fig. 1: Structures of cyclic amine antifungals, wheat mildew responses to fenpropimorph and mitotic fitness of yeast strains with mutations in ERG24. | npj Antimicrobials and Resistance

Fig. 1: Structures of cyclic amine antifungals, wheat mildew responses to fenpropimorph and mitotic fitness of yeast strains with mutations in ERG24.

From: Resistance of ERG24 sterol C-14 reductase to heterocyclic amine antifungals

Fig. 1

A Structures of heterocyclic amine antifungals which inhibit ERG24 and ERG2. Structures are based on those in PubChem (https://pubchem.ncbi.nlm.nih.gov/). B Median effective doses (ED50) of Corbel (750 g L−1 fenpropimorph) for Blumeria graminis f.sp. tritici isolates sampled from John Innes Centre glasshouses in 2014 and 2015 and from the air spora above fields in Norfolk, England in 2015, together with reference isolates from the UK, Switzerland and the USA which were resistant or sensitive to phenylpropylamine antifungals. C Logistic growth curves of Saccharomyces cerevisiae S288C base-substituted strains in the absence of any antifungal. See Supplementary Table 6 for statistical analysis and parameter estimates. Confidence intervals for final OD600 and ED50 are shown, but the interval for the gradient was too narrow to be displayed (mean gradient = 0.274 +/− 0.003 h−1).

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