Fig. 2: HBOC prevalence and age of breast cancer diagnosis in the Vietnamese women. | BJC Reports

Fig. 2: HBOC prevalence and age of breast cancer diagnosis in the Vietnamese women.

From: Breast cancer risk assessment based on susceptibility genes and polygenic risk score in Vietnamese women

Fig. 2

a 5.4% of BC women carried at least 1 pathogenic variant in the HBOC gene panel, indicative of HBOC (n = 802). b Top mutated genes in the BC patients with HBOC were BRCA1 and BRCA2, followed by PALB2 and TP53. No pathogenic variants were detected in STK11, PTEN, and CDH1. c Histogram comparing the distribution of age at diagnosis between HBOC and no-HBOC BC patients. Wilcoxon rank sum test, *p < 0.05. d The proportion of BC patients with HBOC was found the highest in the age groups of 20–29 and 30–39 years.

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