Fig. 4: Chromosomal gains and expression of FGFR genes in ULs.
From: Activation of FGFR genes by genetic and epigenetic alterations in uterine leiomyomas
a Chromosomal gains overlapping FGFR genes in ULs with SNP array data (n = 2030). b FGFR1 expression levels in different UL subtypes and normal myometrium samples. ULs with chromosomal gains overlapping FGFR1 are circled with black line. Of these, sample names are depicted for the cases that show clear overexpression. c FGFR1 qPCR results for the ULs with an amplification of FGFR1 but no RNA-seq data. My5007m1 was used as a positive control, and random MED12 and HMGA2 ULs (My6282m7, My6326m1) as negative controls. The MED12 UL was used as a reference sample for calculating the relative quantification (RQ) values. d–f FGFR2-FGFR4 expression levels in different UL subtypes and normal myometrium samples. None of the ULs with gained regions overlapping these genes showed clear overexpression.
