Fig. 5: Methylation of FGFR2 in ULs.
From: Activation of FGFR genes by genetic and epigenetic alterations in uterine leiomyomas
a Total FGFR2 expression level plotted against FGFR2 promoter (1Kbp upstream from TSS) methylation level for each UL and myometrium sample with both RNA-seq and Nanopore data. Similar figures for each promoter region of alternative FGFR2 transcripts can be found in the Supplementary material (Fig. S5). A group of ULs, mostly HMGA2/1 and unknown subtypes show promoter hypomethylation and overexpression of FGFR2 (circled in purple). b Methylation levels per CpG island 15Kbp upstream and downstream from TSS in different UL subtypes and normal myometrium samples (only Nanopore batch 1 data). The samples circled with purple that were in batch 1 (the seven HMGA2 samples) in (a) are separated to their own subclass ‘hypomethylated_overexpressing’. c Methylation levels per CpG island 15Kbp upstream and downstream from TSS for each sample of Nanopore batch 1 data. HMGA2 ULs show clearly lower methylation of FGFR2.
