Fig. 2: RNA-seq analysis of glioblastoma patients treated with Resveratrol-Copper identifies differential genes and pathways. | BJC Reports

Fig. 2: RNA-seq analysis of glioblastoma patients treated with Resveratrol-Copper identifies differential genes and pathways.

From: Attenuation of malignant phenotype of glioblastoma following a short course of the pro-oxidant combination of Resveratrol and Copper

Fig. 2

a MDS plot showing clusters between R-Cu treated (Teal) and untreated samples (Red). b Volcano plot of statistically significant differentially expressed genes. Red dots represent up-regulated genes with log2 (fold change) > 2 and p-adjusted < 0.05, and blue dots represent down-regulated genes with log2 (fold change) < -2 and p-adjusted < 0.05. c, d Gene set enrichment analysis (GSEA) plots showing de-enrichment of metastasis pathways (c) and cellular metaprogramming and heterogeneity pathways (d) respectively in R-Cu samples compared to untreated samples. For each gene set, Normalised Enrichment Score (NES), nominal p-value, and False Discovery Rate (FDR) are shown on the plot.

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