Fig. 3: Transcriptomic signature indicates activation of intrinsic apoptosis and proteasomal degradation cascade upon R-Cu treatment. | BJC Reports

Fig. 3: Transcriptomic signature indicates activation of intrinsic apoptosis and proteasomal degradation cascade upon R-Cu treatment.

From: Attenuation of malignant phenotype of glioblastoma following a short course of the pro-oxidant combination of Resveratrol and Copper

Fig. 3

a Enrichment plot generated using GSEA showing upregulation of hallmark apoptosis gene set. b Upregulation of proteosome degradation pathways. c Upregulation of Proteasomal System pathway. d Upregulation of Malignant Metaprogram 8 Proteasomal Degradation pathway, respectively in R-Cu treated samples. For each gene set, Normalised Enrichment Score (NES), nominal p-value, and False Discovery Rate (FDR) are shown on the plot. e. Network map showing genes involved in apoptosis and proteasomal degradation pathways.

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