Fig. 1: Schematic of oxytocin-bound OXTR structure with mutation sites.
From: Predicting oxytocin binding dynamics in receptor genetic variants through computational modeling
a A visual representation of the OXTR and oxytocin ligand as well as the specific locations of mutation sites. The image depicts a side-view perspective, parallel to the plane of the plasma membrane. The OXTR protein and the hormone oxytocin are shown as ribbon-like structures. b A top view of the OXTR/oxytocin complex as observed from the extracellular space. c Variant amino acid residue substitutions and their locations in the crystal structure of OXTR (PDB: 7RYC), generated using UCSF Chimera software. The color-coded boxes correspond to several OXTR variants: blue denotes the L206V variant, red denotes the V281M variant, magenta denotes the E339K variant, purple denotes the V45L variant, and green denotes the P108A variant.
