Fig. 2: OXT–OXTR binding affinities differ based on species, cell type, and gestational status (meta-analysis model simulation data).
From: Predicting oxytocin binding dynamics in receptor genetic variants through computational modeling
Forest plot of equilibrium dissociation constant (Kd) for OXT-OXTR binding in different cell lines and species. a The cells included in the figure are myometrial cells from term human, 1st trimester human, nonpregnant human, guinea pig, cattle, sheep, rat, and HEK293T cells transfected to express the OXTR. Blank circle shows mean and blue horizontal lines represent 95% credible intervals (CI). Blank diamond represents global mean of equilibrium dissociation constant, Kd = 1.48 nM with 95% CI [0.86, 2.15]. b The myometrial cells from humans only (term human, 1st trimester human, and nonpregnant human) were shown in the forest plot of equilibrium dissociation constant (Kd) for OXT-OXTR binding. The blank circle shows mean and blue horizontal lines represent 95% credible intervals (CI). Blank diamond represents global mean of equilibrium dissociation constant, Kd = 1.8 nM with 95% CI [0.66, 3.43].
