Table 1 Wild type and variant OXTR receptor concentration on the cell surface in receptors/cell and in nanomolar (nM) (published experimental data)
From: Predicting oxytocin binding dynamics in receptor genetic variants through computational modeling
Cell lines OXTR variants | [OXTR] in transfected HEK293 cells (membrane receptors/cell) | [OXTR] in transfected HEK293 cells (nM) | % change in [OXTR] w.r.t WT (transfected HEK293 cells) | [OXTR] in transfected myometrial cells (membrane receptors/cell) | [OXTR] in transfected Myometrial cells (nM) | % change in [OXTR] w.r.t WT (transfected myometrial cells) |
|---|---|---|---|---|---|---|
WT | 159,539 | 254 | 0% | 14,098 | 1.68 | 0% |
V281M | 80,845 | 128 | −49% | 6289 | 0.75 | −55% |
E339K | 105,494 | 168 | −33% | 9965 | 1.19 | −29% |
V45L | 148,931 | 237 | −7% | 16,477 | 1.96 | 17% |
P108A | 194,048 | 309 | 22% | 22,333 | 2.66 | 58% |
L206V | 222,881 | 355 | 39% | 25,577 | 3.04 | 81% |
