Fig. 3: Schematic diagram of the materno-foetal physiologically-based pharmacokinetic (m-f-PBPK) model.

a Illustration of the maternal physiologically-based pharmacokinetic (PBPK) model representing tissues and organs as compartments with the arrows indicating the direction of blow flow. b Schematic diagram of the foetal compartment as modelled in the uterus. (Adapted from Atoyebi, et al.37 and recreated on Biorender.com). IM: intramuscular.