Table 1 Comprehensive table summarizing how different flaviviruses modulate mitochondrial processes to enhance their replication
From: Flaviviruses manipulate mitochondrial processes to evade the innate immune response
Virus | Effect on mitochondria | Viral protein? | Reference |
|---|---|---|---|
Dengue virus | Fragmentation/reduced fusion | Singh 2022, Yu 2015 | |
Reduced Mfn1 protein levels | NS2B3 | Barbier 2017, Yu 2015, Singh 2022 | |
Reduced Mfn2 protein levels | NS2B3 | Barbier 2017, Yu 2015, Singh 2022 | |
Reduced pDrp1 | Barbier 2017, Singh 2022 | ||
mtDNA release | Sun 2017, Singh 2022, Lai 2021. | ||
Elongation | NS4B | Barbier 2017, Chatel-Chaix 2016 | |
ROS accumulation | Meuren 2022, Khan 2021 | ||
MMP disruption | El Bacha 2007, Hottz 2013 | ||
Zika virus | Fragmentation | Garcia 2020, Ledur 2020, Yang 2020, Lee 2023, Huang 2023 | |
Reduced Mfn2 protein levels | Yang 2020 | ||
Increased pDrp1 | NS4A | Yang 2020 | |
Reduced Opa1 | Yang 2020 | ||
MMP disruption | Yau 2021, | ||
ROS accumulation | Ledur 2020, Lee 2023 | ||
Increased mitophagy | NS4A | Lee 2023 | |
Reduced mitophagy | NS5 | Ponia 2021 | |
mtDNA release | Lee 2023 | ||
Japanese encephalitis virus | Fragmentation | Agarwal 2022 | |
Reduced Mfn1 protein levels | Agarwal 2022 | ||
Reduced Mfn2 protein levels | Agarwal 2022 | ||
Increased pDrp1 | Agarwal 2022 | ||
Increased Parkin | Agarwal 2022 | ||
Increased mitophagy | NS4A | Agarwal 2022 | |
MMP disruption | Yang 2009 | ||
ROS accumulation | Yang 2009, Singh 2023 | ||
West Nile virus | MMP disruption | capsid | Yang 2002 |
Tick-borne encephalitis virus | Enlarged, with deformed cristae | Palus 2014, Ruzek 2009 | |
MMP disruption | Berankova 2024 | ||
ROS accumulation | Berankova 2024 | ||
Yellow fever virus | Fragmentation | Gomez 2023 |
